Safety of Lactiplantibacillus plantarum K014 in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial.

“Hepatocellular injury markers (AST and ALT) remained within normal limits, although ALT showed a small but statistically significant decrease in the probiotic group compared to a slight increase in the placebo group (Δ0–6: −0.32 vs. 5.03 U/L, p = 0.035).”

“Notably, total protein, albumin, and globulin levels increased significantly in the probiotic group relative to placebo (Δ0–6: total protein 3.54 vs. 0.63 g/L, p = 0.014; albumin 2.94 vs. 0.97 g/L, p = 0.017; globulin 1.61 vs. −0.36 g/L, p = 0.005), indicating a possible supportive effect on protein metabolism and immune-related globulin synthesis.”

“Throughout the 24-week intervention, lipid profiles, including total cholesterol, triglycerides, HDL-cholesterol, and LDL-cholesterol, remained stable and within normal reference ranges in both the placebo and probiotic groups, with no statistically significant differences observed between groups (Table 3).”

“Throughout the 24-week intervention, lipid profiles, including total cholesterol, triglycerides, HDL-cholesterol, and LDL-cholesterol, remained stable and within normal reference ranges in both the placebo and probiotic groups, with no statistically significant differences observed between groups (Table 3).”

“Throughout the 24-week intervention, lipid profiles, including total cholesterol, triglycerides, HDL-cholesterol, and LDL-cholesterol, remained stable and within normal reference ranges in both the placebo and probiotic groups, with no statistically significant differences observed between groups (Table 3).”

“Throughout the 24-week intervention, lipid profiles, including total cholesterol, triglycerides, HDL-cholesterol, and LDL-cholesterol, remained stable and within normal reference ranges in both the placebo and probiotic groups, with no statistically significant differences observed between groups (Table 3).”