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Papers/PMID:41535271

Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial.

Nature communications2026The record

2 findings · 1 compound · 2 endpoints

What it reported

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What moved

2 findings

  • Avena sativa — decreases LDL cholesterol

    Evidence strength: moderate.Findingreplicated ×1
    “A significant reduction in LDL-C (−16.26 [−23.60, −10.32] mg/dL, Padj. = 0.011 (Bonferroni–Holm)) and TC (−15.61 [−24.17, −7.80] mg/dL, Padj. = 0.02) levels in OG compared with CG were also identified using LnRadj..”
    Quoted verbatim from Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial..
    Study
    RCT
    Duration
    2 days
    Dose
    three oat meals daily for two days, each 100 g rolled oat flakes boiled in water
    Population
    Adults with metabolic syndrome in the short-term, high-dose, hypocaloric two-day oat diet study (oat group vs control group eating oat-free control meals); parallel design

    Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial.2026PMID:4153527110.1038/s41467-026-68303-9Industry fundedPermalink

  • Avena sativa — decreases total cholesterol (TC)

    Evidence strength: moderate.Findingreplicated ×1
    “A significant reduction in LDL-C (−16.26 [−23.60, −10.32] mg/dL, Padj. = 0.011 (Bonferroni–Holm)) and TC (−15.61 [−24.17, −7.80] mg/dL, Padj. = 0.02) levels in OG compared with CG were also identified using LnRadj..”
    Quoted verbatim from Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial..
    Study
    RCT
    Duration
    2 days
    Dose
    three oat meals daily for two days, each 100 g rolled oat flakes boiled in water
    Population
    Adults with metabolic syndrome in the short-term, high-dose, hypocaloric two-day oat diet study (oat group vs control group eating oat-free control meals); parallel design

    Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial.2026PMID:4153527110.1038/s41467-026-68303-9Industry fundedPermalink