PapersPMID:41168365
Regular collagen peptide administration exerts anti-obesity effects in high-caloric diet-fed rodents-a systematic review with meta-analysis of animal trials.
- findings
- 7
- compound
- 1
- endpoints
- 7
- no difference found
- 1
- Study, every finding
- animal · not in humans
- Population, every finding
- Genetically unmodified mice and rats on a high-fat or high-caloric diet in both arms; pooled estimate from the highest collagen peptide dose of each trial
What moved
How to read these marks →- Increases HDL cholesterol
very limited
“High-density lipoprotein (HDL) gauged in 98 rodents in six studies has been shown to be elevated in CP groups (p = 0.04; SMD = 1.14; CI = 0.06, 2.21).”
- Participants
- 98
- Effect
- 1.14 standardised mean difference, 95% CI 0.06 to 2.21
- Decreases triglycerides
very limited
“Regarding triacylglycerol (TG), 13 studies involving 204 rodents demonstrated a significantly lower TG in the CP group (p < 0.01; SMD = −2.16; CI = −3.76, −0.55).”
- Participants
- 204
- Effect
- −2.16 standardised mean difference, 95% CI −3.76 to −0.55
- Decreases LDL cholesterol
very limited
“Seven trials measuring LDL levels in 118 rodents resulted in a significantly lower LDL amount following prolonged CP administration (p < 0.01; SMD = −2.02; CI = −3.15, −0.88).”
- Participants
- 118
- Effect
- −2.02 standardised mean difference, 95% CI −3.15 to −0.88
“Four studies (64 rodents) investigating adipokines (leptin and adiponectin) showed significant differences following CP supplementation for adiponectin (increased, p < 0.01; SMD = 1.04; CI = 0.47, 1.6) and leptin (decreased, p = 0.01; SMD = −1.33; CI = −2.36, −0.31; both Fig. 4B, C, respectively).”
- Decreases serum leptin
very limited
- Participants
- 64
- Effect
- −1.33 standardised mean difference, 95% CI −2.36 to −0.31
- Increases serum adiponectin
very limited
- Participants
- 64
- Effect
- 1.04 standardised mean difference, 95% CI 0.47 to 1.6
- Decreases body mass
insufficient
“As seen in Fig. 1A and Table 1, body mass has been reduced significantly in the CP group (p < 0.01; SMD = −1.87; CI = −2.8, −0.94).”
- Effect
- −1.87 standardised mean difference, 95% CI −2.8 to −0.94
What did not
- No detected effect on total cholesterol (TC)
very limited
“Twelve studies comprising 188 rodents investigating total cholesterol reported no significant differences between control and CP group (p = 0.08; SMD = −1.49; CI = −3.17, 0.18).”
- Participants
- 188
- Effect
- −1.49 standardised mean difference, 95% CI −3.17 to 0.18
Study record
- Design
- meta-analysis
- Species
- animal
- Population
- high-fat/high-caloric diet-fed rats and mice; 21 studies (n approx 354) in the systematic review, 19 studies (n=338) in the meta-analysis
- Participants
- 338
- Comparator
- not stated in the paper / placebo
- Duration
- not reported
- Endpoints measured
- 20