Papers/PMID:41010449
Hepatic Copper Accumulation Predicts Fibrosis Progression and Mortality in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Nutrients2025The record
2 findings · 1 compound · 2 endpoints · 1 null
What it reported
How to read these marksWhat moved
1 finding
Cu(2+) — increases all-cause mortality
Evidence strength: limited.Findingreplicated ×1“In multivariable Cox regression adjusting for demographic and clinical covariates (Model-3), HCLs ≥ 50 µg/g was associated with an 18.5-fold increased hazard of all-cause mortality (HR = 18.51; p = 0.032).”
Quoted verbatim from Hepatic Copper Accumulation Predicts Fibrosis Progression and Mortality in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).. - Study
- cohort
- Population
- Adults with biopsy-proven MASLD, high (>= 50 ug/g dry tissue) versus normal (< 50 ug/g) hepatic copper on liver biopsy; endogenous hepatic copper, nobody dosed
Effect 18.51 hazard ratio
Hepatic Copper Accumulation Predicts Fibrosis Progression and Mortality in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).2025PMID:4101044910.3390/nu17182923Permalink
What did not
1 finding
Cu(2+) — no detected effect on incidence of cardiovascular disease (composite)
Evidence strength: moderate.FindingNull result“There were no significant differences between copper groups in the incidence of new cirrhosis (Log-Rank p = 0.734) or cardiovascular events (Log-Rank p = 0.747) during follow-up.”
Quoted verbatim from Hepatic Copper Accumulation Predicts Fibrosis Progression and Mortality in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).. - Study
- cohort
- Population
- Adults with biopsy-proven MASLD, high (>= 50 ug/g dry tissue) versus normal (< 50 ug/g) hepatic copper on liver biopsy; endogenous hepatic copper, nobody dosed
Hepatic Copper Accumulation Predicts Fibrosis Progression and Mortality in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).2025PMID:4101044910.3390/nu17182923Permalink