Papers/PMID:40945966
Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.
The journal of prevention of Alzheimer's disease2026The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
folic acid — increases montreal Cognitive Assessment total score
Evidence strength: moderate.Finding“Specifically, total MoCA score (ITT: β = 1.27; 95 % CI = 0.52, 2.03; PP: β = 1.15; 95 % CI = 0.37, 1.93) and total MMSE score (ITT: β = 0.76; 95 % CI = 0.14, 1.39; PP: β = 0.65; 95 % CI = 0.02, 1.28) were improved among patients with CSVD-CI in the FA intervention group compared with those in the placebo group at follow-ups after adjustment of potential confounders.”
Quoted verbatim from Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.. - Study
- RCT
- Dose
- 0.4 mg tablet, two tablets daily, six months
- Population
- Adults aged 40-80 years with cerebral small vessel disease-related cognitive impairment, intention-to-treat analysis at 6 months
Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.2026PMID:4094596610.1016/j.tjpad.2025.100369Permalink
folic acid — increases Mini-Mental State Examination total score
Evidence strength: moderate.Finding“Specifically, total MoCA score (ITT: β = 1.27; 95 % CI = 0.52, 2.03; PP: β = 1.15; 95 % CI = 0.37, 1.93) and total MMSE score (ITT: β = 0.76; 95 % CI = 0.14, 1.39; PP: β = 0.65; 95 % CI = 0.02, 1.28) were improved among patients with CSVD-CI in the FA intervention group compared with those in the placebo group at follow-ups after adjustment of potential confounders.”
Quoted verbatim from Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.. - Study
- RCT
- Dose
- 0.4 mg tablet, two tablets daily, six months
- Population
- Adults aged 40-80 years with cerebral small vessel disease-related cognitive impairment, intention-to-treat analysis at 6 months
Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.2026PMID:4094596610.1016/j.tjpad.2025.100369Permalink