Papers/PMID:37922013
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.
Diabetologia2024The record
6 findings · 1 compound · 6 endpoints · 4 null
What it reported
How to read these marksWhat moved
2 findings
magnesium(2+) — increases serum magnesium concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“Serum magnesium level was higher after magnesium supplementation compared with placebo (0.75±0.02 vs 0.70±0.02 mmol/l, p=0.016); this was also the case for the urinary magnesium excretion (magnesium/creatinine ratio 0.23±0.02 vs 0.15±0.02, p=0.005).”
Quoted verbatim from Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.. - Study
- crossover
- Participants
- 14
- Duration
- 6 weeks
- Dose
- 15 mmol magnesium per day (360 mg) as magnesium gluconate liquid, 50 ml three times daily, for 6 weeks
- Population
- Adults with insulin-treated type 2 diabetes and serum magnesium at or below 0.79 mmol/l, 14 participants
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.2024PMID:37922013Permalink
magnesium(2+) — decreases HDL cholesterol
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“HDL-cholesterol was significantly lower after magnesium compared with placebo (1.14±0.08 vs 1.20±0.09 mmol/l, p=0.026), but no effect on total cholesterol, LDL-cholesterol and triglycerides was found (Table 2).”
Quoted verbatim from Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.. - Study
- crossover
- Participants
- 14
- Duration
- 6 weeks
- Dose
- 15 mmol magnesium per day (360 mg) as magnesium gluconate liquid, 50 ml three times daily, for 6 weeks
- Population
- Adults with insulin-treated type 2 diabetes and serum magnesium at or below 0.79 mmol/l, 14 participants
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.2024PMID:37922013Permalink
What did not
4 findings
magnesium(2+) — no detected effect on total cholesterol (TC)
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×2“HDL-cholesterol was significantly lower after magnesium compared with placebo (1.14±0.08 vs 1.20±0.09 mmol/l, p=0.026), but no effect on total cholesterol, LDL-cholesterol and triglycerides was found (Table 2).”
Quoted verbatim from Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.. - Study
- crossover
- Participants
- 14
- Duration
- 6 weeks
- Dose
- 15 mmol magnesium per day (360 mg) as magnesium gluconate liquid, 50 ml three times daily, for 6 weeks
- Population
- Adults with insulin-treated type 2 diabetes and serum magnesium at or below 0.79 mmol/l, 14 participants
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.2024PMID:37922013Permalink
magnesium(2+) — no detected effect on LDL cholesterol
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×1“HDL-cholesterol was significantly lower after magnesium compared with placebo (1.14±0.08 vs 1.20±0.09 mmol/l, p=0.026), but no effect on total cholesterol, LDL-cholesterol and triglycerides was found (Table 2).”
Quoted verbatim from Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.. - Study
- crossover
- Participants
- 14
- Duration
- 6 weeks
- Dose
- 15 mmol magnesium per day (360 mg) as magnesium gluconate liquid, 50 ml three times daily, for 6 weeks
- Population
- Adults with insulin-treated type 2 diabetes and serum magnesium at or below 0.79 mmol/l, 14 participants
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.2024PMID:37922013Permalink
magnesium(2+) — no detected effect on body mass
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Serum potassium (4.1±0.1 vs 4.0±0.1 mmol/l, p=0.642) and calcium concentrations (corrected for serum albumin 2.4±0.0 vs 2.4±0.0 mmol/l, p=0.960) were similar after magnesium compared with placebo, as was body weight (92.5±3.9 vs 93.2±4.1 kg, p=0.142) (Table 2).”
Quoted verbatim from Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.. - Study
- crossover
- Participants
- 14
- Duration
- 6 weeks
- Dose
- 15 mmol magnesium per day (360 mg) as magnesium gluconate liquid, 50 ml three times daily, for 6 weeks
- Population
- Adults with insulin-treated type 2 diabetes and serum magnesium at or below 0.79 mmol/l, 14 participants
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.2024PMID:37922013Permalink
magnesium(2+) — no detected effect on triglycerides
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×1“HDL-cholesterol was significantly lower after magnesium compared with placebo (1.14±0.08 vs 1.20±0.09 mmol/l, p=0.026), but no effect on total cholesterol, LDL-cholesterol and triglycerides was found (Table 2).”
Quoted verbatim from Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.. - Study
- crossover
- Participants
- 14
- Duration
- 6 weeks
- Dose
- 15 mmol magnesium per day (360 mg) as magnesium gluconate liquid, 50 ml three times daily, for 6 weeks
- Population
- Adults with insulin-treated type 2 diabetes and serum magnesium at or below 0.79 mmol/l, 14 participants
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.2024PMID:37922013Permalink