Papers/PMID:36927185
Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats.
Immunopharmacology and immunotoxicology2023The record
3 findings · 1 compound · 3 endpoints
What it reported
How to read these marksWhat moved
3 findings
sodium benzoate — increases aspartate aminotransferase
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Finding“Administration of SB to rats with hepatocyte injury exacerbated liver damage with a significant increase in the activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP).”
Quoted verbatim from Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats.. - Study
- animal · not in humans
- Duration
- 14 days
- Dose
- 600 mg/kg, oral, 14 days
- Population
- rats with LPS-induced (0.25 mg/kg) hepatocyte injury given sodium benzoate 600 mg/kg orally for 14 days; LPS background present in both compared arms
Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats.2023PMID:36927185Permalink
sodium benzoate — increases alanine aminotransferase
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Finding“Administration of SB to rats with hepatocyte injury exacerbated liver damage with a significant increase in the activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP).”
Quoted verbatim from Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats.. - Study
- animal · not in humans
- Duration
- 14 days
- Dose
- 600 mg/kg, oral, 14 days
- Population
- rats with LPS-induced (0.25 mg/kg) hepatocyte injury given sodium benzoate 600 mg/kg orally for 14 days; LPS background present in both compared arms
Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats.2023PMID:36927185Permalink
sodium benzoate — increases serum alkaline phosphatase
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Finding“Administration of SB to rats with hepatocyte injury exacerbated liver damage with a significant increase in the activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP).”
Quoted verbatim from Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats.. - Study
- animal · not in humans
- Duration
- 14 days
- Dose
- 600 mg/kg, oral, 14 days
- Population
- rats with LPS-induced (0.25 mg/kg) hepatocyte injury given sodium benzoate 600 mg/kg orally for 14 days; LPS background present in both compared arms
Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats.2023PMID:36927185Permalink