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PapersPMID:36927185

Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats.

Immunopharmacology and immunotoxicology2023The record ↗

01 · findings
3
02 · compound
1
03 · endpoints
3
04 · null
0
PMID:36927185 · 3 findings, in bands by direction at evidence strength
  1. Finding, insufficient evidenceraisesAspartate aminotransferase
  2. Finding, insufficient evidenceraisesAlanine aminotransferase
  3. Finding, insufficient evidenceraisesSerum alkaline phosphatase
Dose studied, every finding
600 mg/kg, oral, 14 days
Population, every finding
rats with LPS-induced (0.25 mg/kg) hepatocyte injury given sodium benzoate 600 mg/kg orally for 14 days; LPS background present in both compared arms

What moved

3 findingsHow to read these marks →

  • sodium benzoate — increases aspartate aminotransferase

    insufficientFinding

    “Administration of SB to rats with hepatocyte injury exacerbated liver damage with a significant increase in the activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP).”
    Quoted verbatim from Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats.
    Study
    animal · not in humans
    Duration
    14 days

    Permalink

  • sodium benzoate — increases alanine aminotransferase

    insufficientFinding

    “Administration of SB to rats with hepatocyte injury exacerbated liver damage with a significant increase in the activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP).”
    Quoted verbatim from Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats.
    Study
    animal · not in humans
    Duration
    14 days

    Permalink

  • sodium benzoate — increases serum alkaline phosphatase

    insufficientFinding

    “Administration of SB to rats with hepatocyte injury exacerbated liver damage with a significant increase in the activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP).”
    Quoted verbatim from Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats.
    Study
    animal · not in humans
    Duration
    14 days

    Permalink

Study record

Read under
sodium benzoate
Design
animal study, in vivo
Species
animal
Population
rats (n=28), LPS-induced hepatic injury model, 4 arms: control, SB, LPS, LPS+SB
Participants
28
Comparator
an active treatment / placebo
Duration
14 days
Endpoints measured
3
Record
extracted
Readings recorded
2