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sodium benzoateFinding

Sodium benzoate increases aspartate aminotransferase

raisesInsufficient evidenceFinding

01 · The sentence it was drawn from

“Administration of SB to rats with hepatocyte injury exacerbated liver damage with a significant increase in the activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP).”
Quoted verbatim from Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats. · PMID 36927185 · 2023
Aspartate aminotransferase · this finding in ember among the 40 findings on it, in bands by direction at evidence strength

Findingsodium benzoate

Aspartate aminotransferase

raises

Effect as reported

not reported

Who
rats with LPS-induced (0.25 mg/kg) hepatocyte injury given sodium benzoate 600 mg/kg orally for 14 days; LPS background present in both compared arms
Dose studied
600 mg/kg, oral, 14 days

Insufficient evidencePMID 36927185 · 2023

02 · The finding

raises

Insufficient

Mechanistic inference, no evidence found, or evidence weakened below very limited

Study
animal · not in humans
Participants
not reported
Duration
14 days
Kind
Finding Reported directly by a cited source.

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limited
  • insufficientthis finding

03 · The paper

Immunopharmacology and immunotoxicology · 2023
What else it reported3 findings · 1 compound · 3 endpoints

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M37X3DA11YCXGP99QNJEMS4D