sodium benzoate/Finding
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Increases aspartate aminotransferase
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Finding“Administration of SB to rats with hepatocyte injury exacerbated liver damage with a significant increase in the activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP).”
Quoted verbatim from Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats.. - Study
- animal · not in humans
- Duration
- 14 days
- Dose
- 600 mg/kg, oral, 14 days
- Population
- rats with LPS-induced (0.25 mg/kg) hepatocyte injury given sodium benzoate 600 mg/kg orally for 14 days; LPS background present in both compared arms
Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats.2023PMID:36927185Permalink
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To cite this finding: https://catalystproject.ai/e/01M37X3DA11YCXGP99QNJEMS4D