Skip to content
Catalyst
Sign in

sodium benzoateFinding

Sodium benzoate increases serum alkaline phosphatase

raisesInsufficient evidenceFinding

01 · The sentence it was drawn from

“Administration of SB to rats with hepatocyte injury exacerbated liver damage with a significant increase in the activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP).”
Quoted verbatim from Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats. · PMID 36927185 · 2023
Serum alkaline phosphatase · this finding in ember among the 7 findings on it, in bands by direction at evidence strength

Findingsodium benzoate

Serum alkaline phosphatase

raises

Effect as reported

not reported

Who
rats with LPS-induced (0.25 mg/kg) hepatocyte injury given sodium benzoate 600 mg/kg orally for 14 days; LPS background present in both compared arms
Dose studied
600 mg/kg, oral, 14 days

Insufficient evidencePMID 36927185 · 2023

02 · The finding

raises

Insufficient

Mechanistic inference, no evidence found, or evidence weakened below very limited

Study
animal · not in humans
Participants
not reported
Duration
14 days
Kind
Finding Reported directly by a cited source.

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limited
  • insufficientthis finding

03 · The paper

Immunopharmacology and immunotoxicology · 2023
What else it reported3 findings · 1 compound · 3 endpoints

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M37X3DVF27SNRMJWACER44G1