Papers/PMID:34468959
A pilot study on the melatonin treatment in patients with early septic shock: results of a single-center randomized controlled trial.
Irish journal of medical science2022The record
1 finding · 1 compound · 1 endpoint · 1 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
melatonin — no detected effect on all-cause mortality
Evidence strength: moderate.FindingNull resultreplicated ×2“Despite the lower mortality rate in the melatonin recipients compared to the placebo recipients during the 28-day follow-up, no statistically significant difference was observed between the study groups (p value = 0.51).”
Quoted verbatim from A pilot study on the melatonin treatment in patients with early septic shock: results of a single-center randomized controlled trial.. - Study
- RCT
- Duration
- 5 days
- Dose
- 50 mg as oral solution at 9 p.m. for five consecutive nights
- Population
- Adults aged 18-75 with early septic shock in a single ICU, all receiving standard-of-care septic shock treatment in both arms; 28-day all-cause mortality
A pilot study on the melatonin treatment in patients with early septic shock: results of a single-center randomized controlled trial.2022PMID:3446895910.1007/s11845-021-02758-1Permalink