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Papers/PMID:33036854

Intravenous thiamine for septic shock: A meta-analysis of randomized controlled trials.

The American journal of emergency medicine2020The record

2 findings · 1 compound · 2 endpoints · 2 null

What it reported

How to read these marks

Every finding here is a null result.

What did not

2 findings

  • thiamine — no detected effect on intensive care unit length of stay

    Evidence strength: very limited.FindingNull result
    “Overall, compared with control group in patients with septic shock, intravenous thiamine revealed no substantial impact on mortality (odd ratio [OR] = 0.87; 95% confidence interval [CI) = 0.62 to 1.21; P = 0.40), lactate change (standard mean difference [SMD] = 0.04; 95% CI = -0.28 to 0.35; P = 0.82), Sequential Organ Failure Assessment (SOFA) change (SMD = 0.02; 95% CI = -0.18 to 0.21; P = 0.87), intensive care unit (ICU) stay (SMD = -0.02; 95% CI = -0.33 to 0.30; P = 0.90) or renal replacement therapy (OR = 0.47; 95% CI = 0.07 to 3.15; P = 0.43).”
    Quoted verbatim from Intravenous thiamine for septic shock: A meta-analysis of randomized controlled trials..
    Study
    meta-analysis
    Population
    Patients with septic shock; pooled four randomized controlled trials of intravenous thiamine

    Effect -0.02 standardised mean difference, 95% CI -0.33 to 0.3

    Intravenous thiamine for septic shock: A meta-analysis of randomized controlled trials.2020PMID:3303685410.1016/j.ajem.2020.08.050Permalink

  • thiamine — no detected effect on all-cause mortality

    Evidence strength: very limited.FindingNull resultreplicated ×1
    “Overall, compared with control group in patients with septic shock, intravenous thiamine revealed no substantial impact on mortality (odd ratio [OR] = 0.87; 95% confidence interval [CI) = 0.62 to 1.21; P = 0.40), lactate change (standard mean difference [SMD] = 0.04; 95% CI = -0.28 to 0.35; P = 0.82), Sequential Organ Failure Assessment (SOFA) change (SMD = 0.02; 95% CI = -0.18 to 0.21; P = 0.87), intensive care unit (ICU) stay (SMD = -0.02; 95% CI = -0.33 to 0.30; P = 0.90) or renal replacement therapy (OR = 0.47; 95% CI = 0.07 to 3.15; P = 0.43).”
    Quoted verbatim from Intravenous thiamine for septic shock: A meta-analysis of randomized controlled trials..
    Study
    meta-analysis
    Population
    Patients with septic shock; pooled four randomized controlled trials of intravenous thiamine

    Effect 0.87 odds ratio, 95% CI 0.62 to 1.21

    Intravenous thiamine for septic shock: A meta-analysis of randomized controlled trials.2020PMID:3303685410.1016/j.ajem.2020.08.050Permalink