Papers/PMID:27068631
Short-Term High-Dose Vitamin E to Prevent Contrast Medium-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Elective Coronary Angiography: A Randomized Placebo-Controlled Trial.
Journal of the American Heart Association2016The record
3 findings · 1 compound · 3 endpoints · 2 null
What it reported
How to read these marksWhat moved
1 finding
α-tocopherol — decreases total leukocyte count
Evidence strength: moderate.Findingreplicated ×1“Furthermore, decrease in WBC count was significantly greater in the vitamin E group compared with the placebo group.”
Quoted verbatim from Short-Term High-Dose Vitamin E to Prevent Contrast Medium-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Elective Coronary Angiography: A Randomized Placebo-Controlled Trial.. - Study
- RCT
- Duration
- 3 days
- Dose
- 600 mg oral vitamin E 12 hours before plus 400 mg 2 hours before angiography
- Population
- Patients aged 18 or over with chronic kidney disease (eGFR below 60 mL/min per 1.73 m2) undergoing elective coronary angiography at two centres in Iran; 0.9% saline infusion given to both arms; change in WBC count from baseline to follow-up within 72 hours
Short-Term High-Dose Vitamin E to Prevent Contrast Medium-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Elective Coronary Angiography: A Randomized Placebo-Controlled Trial.2016PMID:2706863110.1161/JAHA.115.002919Permalink
What did not
2 findings
α-tocopherol — no detected effect on serum creatinine concentration
Evidence strength: moderate.FindingNull result“Comparing the placebo and vitamin E groups, serum creatinine level (1.3 [IQR 1.1–1.5] versus 1.3 [IQR 1.1–1.4] mg/dL, respectively; P=0.2) and eGFR (49 [IQR 39–55] versus 49 [IQR 41–59] mL/min per 1.73 m2, respectively; P=0.2) within 72 hours were comparable.”
Quoted verbatim from Short-Term High-Dose Vitamin E to Prevent Contrast Medium-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Elective Coronary Angiography: A Randomized Placebo-Controlled Trial.. - Study
- RCT
- Duration
- 3 days
- Dose
- 600 mg oral vitamin E 12 hours before plus 400 mg 2 hours before angiography
- Population
- Patients aged 18 or over with chronic kidney disease (eGFR below 60 mL/min per 1.73 m2) undergoing elective coronary angiography at two centres in Iran; 0.9% saline infusion given to both arms and iodixanol contrast to all; value within 72 hours after angiography
Short-Term High-Dose Vitamin E to Prevent Contrast Medium-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Elective Coronary Angiography: A Randomized Placebo-Controlled Trial.2016PMID:2706863110.1161/JAHA.115.002919Permalink
α-tocopherol — no detected effect on estimated glomerular filtration rate
Evidence strength: limited.FindingNull result“Comparing the placebo and vitamin E groups, serum creatinine level (1.3 [IQR 1.1–1.5] versus 1.3 [IQR 1.1–1.4] mg/dL, respectively; P=0.2) and eGFR (49 [IQR 39–55] versus 49 [IQR 41–59] mL/min per 1.73 m2, respectively; P=0.2) within 72 hours were comparable.”
Quoted verbatim from Short-Term High-Dose Vitamin E to Prevent Contrast Medium-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Elective Coronary Angiography: A Randomized Placebo-Controlled Trial.. - Study
- RCT
- Duration
- 3 days
- Dose
- 600 mg oral vitamin E 12 hours before plus 400 mg 2 hours before angiography
- Population
- Patients aged 18 or over with chronic kidney disease (eGFR below 60 mL/min per 1.73 m2) undergoing elective coronary angiography at two centres in Iran; 0.9% saline infusion given to both arms and iodixanol contrast to all; value within 72 hours after angiography
Short-Term High-Dose Vitamin E to Prevent Contrast Medium-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Elective Coronary Angiography: A Randomized Placebo-Controlled Trial.2016PMID:2706863110.1161/JAHA.115.002919Permalink