Papers/PMID:26786590
Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.
Scientific reports2016The record
5 findings · 1 compound · 5 endpoints · 3 null
What it reported
How to read these marksWhat moved
2 findings
selenium atom — decreases prostate cancer incidence
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1“The result showed that high selenium exposure decreased risk of prostate cancer (pooled OR = 0.72, 95%CI: 0.61–0.86, Fig. 13), with moderate heterogeneity (Q = 81.6, P = 0.000; I 2 % = 69.4).”
Quoted verbatim from Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.. - Study
- meta-analysis
- Population
- 26 estimates from 25 studies, highest versus lowest selenium exposure (exposure modes pooled)
Effect 0.72 odds ratio, 95% CI 0.61 to 0.86
Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.2016PMID:26786590Permalink
selenium atom — decreases breast cancer incidence
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.Finding“The pooled result showed that high selenium exposure decreased risk of breast cancer (pooled OR = 0.88; 95%CI: 0.84–0.93, Fig. 7), with no heterogeneity (Q = 20.83, P = 0.234; I 2 % = 18.4) and publication bias (Begger’s test z c = 1.74; P = 0.081; Egger’s test t = −1.21, P = 0.245).”
Quoted verbatim from Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.. - Study
- meta-analysis
- Population
- 18 estimates from 14 studies, highest versus lowest selenium exposure (exposure modes pooled)
Effect 0.88 odds ratio, 95% CI 0.84 to 0.93
Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.2016PMID:26786590Permalink
What did not
3 findings
selenium atom — no detected effect on colorectal cancer incidence
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull resultreplicated ×1“The result showed that high selenium exposure was not associated with colorectal cancer (pooled OR = 0.89, 95%CI: 0.67–1.17, Fig. 11), with moderate heterogeneity (Q = 26.71, P = 0.009; I 2 % = 55.1), but without publication bias (Begger’s test z c = 0.06; P = 0.951; Egger’s test t = −0.49, P = 0.634).”
Quoted verbatim from Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.. - Study
- meta-analysis
- Population
- 13 estimates from 10 studies, highest versus lowest selenium exposure (exposure modes pooled)
Effect 0.89 odds ratio, 95% CI 0.67 to 1.17
Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.2016PMID:26786590Permalink
selenium atom — no detected effect on all-site cancer incidence
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“The result showed that selenium supplement was not associated with cancer risk (pooled OR = 0.91; 95%CI: 0.80–1.03, Fig. 6), with obvious heterogeneity (Q = 49.35, P = 0.001; I 2 % = 55.4).”
Quoted verbatim from Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.. - Study
- meta-analysis
- Population
- 23 estimates of selenium supplement or dietary intake exposure and all-cancer risk, highest versus lowest category, mostly observational with some RCTs
Effect 0.91 odds ratio, 95% CI 0.8 to 1.03
Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.2016PMID:26786590Permalink
selenium atom — no detected effect on urinary bladder cancer incidence
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull resultreplicated ×1“The result showed that high selenium exposure was not associated with bladder cancer (pooled OR = 0.76, 95%CI: 0.58–1.01, as shown in Fig. 12) with moderate heterogeneity (Q = 25.06, P = 0.003; I 2 % = 64.1), but without publication bias (Begger’s test z c = 0.72; P = 0.474; Egger’s test t = −0.90, P = 0.395).”
Quoted verbatim from Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.. - Study
- meta-analysis
- Population
- 10 estimates from 9 studies, highest versus lowest selenium exposure (exposure modes pooled)
Effect 0.76 odds ratio, 95% CI 0.58 to 1.01
Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression.2016PMID:26786590Permalink