Papers/PMID:25139979
Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.
JPEN. Journal of parenteral and enteral nutrition2016The record
4 findings · 1 compound · 4 endpoints · 4 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
4 findings
L-cysteine — no detected effect on reduced glutathione concentration
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“The CYS and ISO group means were not different for total glutathione, GSH, and GSH:GSSG, neither at enrollment nor infusion day (Table 2).”
Quoted verbatim from Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.. - Study
- RCT
- Dose
- cysteine-HCl 121 mg/kg/day in parenteral nutrition with sodium acetate 2 mEq/kg/day
- Population
- Critically ill neonates on mechanical ventilation and parenteral nutrition (SNAP > 10); intracellular erythrocyte GSH at enrollment and on infusion day, about study day 7; comparator is isonitrogenous additional parenteral amino acids without cysteine
Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.2016PMID:25139979Permalink
L-cysteine — no detected effect on necrotising enterocolitis incidence
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“No difference was found in the CYS and ISO groups with regards to the percent of subjects diagnosed with necrotizing enterocolitis (29% vs. 24%, p=1), intraventricular hemorrhage grade III and IV (19% vs. 24%, p=1), and need for laser treatment for retinopathy of prematurity (24% vs. 24%, p=1).”
Quoted verbatim from Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.. - Study
- RCT
- Dose
- cysteine-HCl 121 mg/kg/day in parenteral nutrition with sodium acetate 2 mEq/kg/day
- Population
- Critically ill neonates on mechanical ventilation and parenteral nutrition (SNAP > 10); comparator is isonitrogenous additional parenteral amino acids without cysteine
Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.2016PMID:25139979Permalink
L-cysteine — no detected effect on intraventricular haemorrhage incidence
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“No difference was found in the CYS and ISO groups with regards to the percent of subjects diagnosed with necrotizing enterocolitis (29% vs. 24%, p=1), intraventricular hemorrhage grade III and IV (19% vs. 24%, p=1), and need for laser treatment for retinopathy of prematurity (24% vs. 24%, p=1).”
Quoted verbatim from Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.. - Study
- RCT
- Dose
- cysteine-HCl 121 mg/kg/day in parenteral nutrition with sodium acetate 2 mEq/kg/day
- Population
- Critically ill neonates on mechanical ventilation and parenteral nutrition (SNAP > 10); severe grades III and IV only; comparator is isonitrogenous additional parenteral amino acids without cysteine
Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.2016PMID:25139979Permalink
L-cysteine — no detected effect on retinopathy of prematurity incidence
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“No difference was found in the CYS and ISO groups with regards to the percent of subjects diagnosed with necrotizing enterocolitis (29% vs. 24%, p=1), intraventricular hemorrhage grade III and IV (19% vs. 24%, p=1), and need for laser treatment for retinopathy of prematurity (24% vs. 24%, p=1).”
Quoted verbatim from Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.. - Study
- RCT
- Dose
- cysteine-HCl 121 mg/kg/day in parenteral nutrition with sodium acetate 2 mEq/kg/day
- Population
- Critically ill neonates on mechanical ventilation and parenteral nutrition (SNAP > 10); event is ROP requiring laser treatment; comparator is isonitrogenous additional parenteral amino acids without cysteine
Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.2016PMID:25139979Permalink