Papers/PMID:17506781
Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin.
British journal of clinical pharmacology2007The record
2 findings · 1 compound · 2 endpoints · 2 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
2 findings
melatonin — no detected effect on interleukin-6 concentration
Evidence strength: very limited.FindingNull result“These results suggest a proinflammatory action, but there were no significant effects of melatonin treatment on clinical assessments of patient symptoms or the concentrations of three proinflammatory cytokines, IL-1beta, IL-6 and TNF-alpha.”
Quoted verbatim from Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin.. - Study
- RCT
- Duration
- 6 months
- Dose
- 10 mg melatonin at night
- Population
- Adults with rheumatoid arthritis on ongoing medication in both arms, monthly samples over 6 months
Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin.2007PMID:1750678110.1111/j.1365-2125.2007.02911.xPermalink
melatonin — no detected effect on tumour necrosis factor alpha concentration
Evidence strength: very limited.FindingNull result“These results suggest a proinflammatory action, but there were no significant effects of melatonin treatment on clinical assessments of patient symptoms or the concentrations of three proinflammatory cytokines, IL-1beta, IL-6 and TNF-alpha.”
Quoted verbatim from Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin.. - Study
- RCT
- Duration
- 6 months
- Dose
- 10 mg melatonin at night
- Population
- Adults with rheumatoid arthritis on ongoing medication in both arms, monthly samples over 6 months
Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin.2007PMID:1750678110.1111/j.1365-2125.2007.02911.xPermalink