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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

21,751–21,800 of 31,435, by identifier

trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine
Direction not assertedBalancedRhea 47544
7alpha-hydroxy-3-oxochol-4-en-24-oate = 3-oxochola-4,6-dien-24-oate + H2O
Direction not assertedBalancedRhea 47548
glycodeoxycholate + H2O = deoxycholate + glycine
Direction not assertedBalancedRhea 47552
taurodeoxycholate + H2O = deoxycholate + taurine
Direction not assertedBalancedRhea 47556
a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+)
Left to rightBalance undeterminableRhea 47560
a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GA2 (d18:1(4E)) + UDP + H(+)
Left to rightBalance undeterminableRhea 47564
a ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GD1b (d18:1(4E)) + UDP + H(+)

Left to rightBalance undeterminableRhea 47568

a ganglioside GD1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1b (d18:1(4E)) + CMP + H(+)

Left to rightBalance undeterminableRhea 47572

a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c (d18:1(4E)) + CMP + H(+)

Left to rightBalance undeterminableRhea 47576

a ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GT2 (d18:1(4E)) + UDP + H(+)

Left to rightBalance undeterminableRhea 47580

a ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GT1c (d18:1(4E)) + UDP + H(+)

Direction not assertedBalance undeterminableRhea 47584

a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1c (d18:1(4E)) + CMP + H(+)

Left to rightBalance undeterminableRhea 47588

a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GP1c (d18:1(4E)) + CMP + H(+)

Left to rightBalance undeterminableRhea 47592

an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + UDP + H(+)

Direction not assertedBalance undeterminableRhea 47596

a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = a ganglioside GM4 (d18:1(4E)) + CMP + H(+)

Left to rightBalance undeterminableRhea 47600

a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GP1calpha (d18:1(4E)) + CMP + H(+)

Direction not assertedBalance undeterminableRhea 47604

3-(3-hydroxyphenyl)-propanoyl-CoA + 3 malonyl-CoA + 3 H(+) = 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA

Direction not assertedBalancedRhea 47608

a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP + H(+)

Direction not assertedBalance undeterminableRhea 47612

ethionamide + NADPH + O2 + H(+) = ethionamide S-oxide + NADP(+) + H2O

Direction not assertedBalancedRhea 47616

2-ethylhexyl sulfate + 2-oxoglutarate + O2 = 2-ethylhexanal + sulfate + succinate + CO2 + H(+)

Direction not assertedBalancedRhea 47620

cis-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O

Direction not assertedBalancedRhea 47624

propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

Direction not assertedBalancedRhea 47628

L-arginine + NAD(+) + H2O = 5-guanidino-2-oxopentanoate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 47632

L-arginine + NADP(+) + H2O = 5-guanidino-2-oxopentanoate + NH4(+) + NADPH + H(+)

Direction not assertedBalancedRhea 47636

adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)

Direction not assertedUnbalancedRhea 47640

adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)

Direction not assertedUnbalancedRhea 47644

D-ribitol 5-phosphate + H2O = ribitol + phosphate

Direction not assertedBalancedRhea 47648

D-ribitol 1-phosphate + H2O = ribitol + phosphate

Direction not assertedBalancedRhea 47652

L-methionine sulfone + acetyl-CoA = N-acetyl-L-methionine sulfone + CoA + H(+)

Direction not assertedBalancedRhea 47656

L-methionine sulfoximine + acetyl-CoA = N-acetyl-L-methionine sulfoximine + CoA + H(+)

Direction not assertedBalancedRhea 47660

N(6)-glutaryl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-glutaryl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]

Left to rightBalance undeterminableRhea 47664

N(6)-succinyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]

Left to rightBalance undeterminableRhea 47668

N(6)-malonyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-malonyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]

Direction not assertedBalance undeterminableRhea 47672

N-acetyl-D-galactosamine + ATP = N-acetyl-D-galactosamine 6-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 47676

D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-phosphate + NH4(+)

Direction not assertedBalancedRhea 47680

[(1->2)-beta-D-glucosyl](n) + phosphate = [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate

Direction not assertedBalance undeterminableRhea 47684

cis-4-hydroxy-L-proline + NADP(+) = Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 47688

neomycin C + AH2 + S-adenosyl-L-methionine = neomycin B + 5'-deoxyadenosine + L-methionine + A + H(+)

Direction not assertedBalancedRhea 47692

(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate

Direction not assertedBalancedRhea 47696

ketocytochalasin + NADPH + O2 + H(+) = iso-precytochalasin + NADP(+) + H2O

Direction not assertedBalancedRhea 47700

iso-precytochalasin + NADPH + O2 + H(+) = cytochalasin Z16 + NADP(+) + H2O

Direction not assertedBalancedRhea 47704

alpha-D-glucose 1-phosphate + ADP + H(+) = ADP-alpha-D-glucose + phosphate

Direction not assertedBalancedRhea 47708

trans-3-hydroxy-L-proline = cis-3-hydroxy-D-proline

Direction not assertedBalancedRhea 47712

4-pregnen-20,21-diol-3-one + NAD(+) = 21-hydroxyprogesterone + NADH + H(+)

Direction not assertedBalancedRhea 47716

isoguanine + H2O + H(+) = xanthine + NH4(+)

Direction not assertedBalancedRhea 47720

glutathione = L-cysteinylglycine + 5-oxo-L-proline

Direction not assertedBalancedRhea 47724

(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)

Direction not assertedBalancedRhea 47728

cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1400) in 16S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 47732

cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1404) in 16S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 47736

2-carboxy-1,4-naphthoquinone + phytyl diphosphate + H(+) = demethylphylloquinone + CO2 + diphosphate

Direction not assertedBalancedRhea 47740

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