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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

16,451–16,500 of 31,435, by identifier

3-hydroxybenzoate + ATP + CoA = 3-hydroxybenzoyl-CoA + AMP + diphosphate
Direction not assertedBalancedRhea 25070
(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O
Direction not assertedBalancedRhea 25074
(2S)-2-isopropyl-3-oxosuccinate + H(+) = 4-methyl-2-oxopentanoate + CO2
Direction not assertedBalancedRhea 25078
dCMP + ATP = dCDP + ADP
Direction not assertedBalancedRhea 25094
UDP + ATP = UTP + ADP
Left to rightBalancedRhea 25098
pyridoxamine + ATP = pyridoxamine 5'-phosphate + ADP + H(+)
Left to rightBalancedRhea 25104
pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+)

→ Left to right

Balanced

Rhea 25108

pyridoxine 5'-phosphate + H2O = pyridoxine + phosphate

Left to rightBalancedRhea 25112

L-lysine + NAD(+) + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 25117

(S)-2-amino-6-oxohexanoate = L-1-piperideine-6-carboxylate + H2O + H(+)

Direction not assertedBalancedRhea 25121

pyridoxamine + phosphate = pyridoxamine 5'-phosphate + H2O

Right to leftBalancedRhea 25135

3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

Direction not assertedBalancedRhea 25143

(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde = quinolinate + H2O + H(+)

Direction not assertedBalancedRhea 25147

L-phenylalanine + 2-oxoglutarate = 3-phenylpyruvate + L-glutamate

Direction not assertedBalancedRhea 25152

(R)-4'-phosphopantothenate + L-cysteine + ATP = N-[(R)-4-phosphopantothenoyl]-L-cysteine + AMP + diphosphate + H(+)

Left to rightBalancedRhea 25156

L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

ReversibleBalancedRhea 25160

butanoyl-CoA + A = (2E)-butenoyl-CoA + AH2

Direction not assertedBalancedRhea 25164

6-hydroxyhexan-6-olide = 6-oxohexanoate + H(+)

Direction not assertedBalancedRhea 25168

N(omega)-methyl-L-arginine + H2O = L-citrulline + methylamine

Left to rightBalancedRhea 25173

4-methyl-2-oxopentanoate + NAD(+) + CoA = 3-methylbutanoyl-CoA + CO2 + NADH

Direction not assertedBalancedRhea 25177

putrescine + acetyl-CoA = N-acetylputrescine + CoA + H(+)

Direction not assertedBalancedRhea 25181

1,2-dichloroethane + H2O = 2-chloroethanol + chloride + H(+)

Direction not assertedBalancedRhea 25185

chloroacetate + H2O = glycolate + chloride + H(+)

Direction not assertedBalancedRhea 25189

(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + NADH + H(+)

Direction not assertedBalancedRhea 25193

5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate

Direction not assertedBalancedRhea 25197

D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose 6-phosphate

Direction not assertedBalancedRhea 25201

UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine + H2O = UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + acetate

Direction not assertedBalancedRhea 25209

UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + H2O = 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UMP + 2 H(+)

Direction not assertedBalancedRhea 25213

serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)

Direction not assertedBalancedRhea 25217

L-cysteate + H(+) = taurine + CO2

Direction not assertedBalancedRhea 25221

L-arabinitol + NAD(+) = L-arabinose + NADH + H(+)

Direction not assertedBalancedRhea 25225

L-arabinitol + NADP(+) = L-arabinose + NADPH + H(+)

Direction not assertedBalancedRhea 25229

N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate

Direction not assertedBalancedRhea 25233

CDP + ATP = CTP + ADP

Left to rightBalancedRhea 25237

(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4(+)

Direction not assertedBalancedRhea 25241

(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

Left to rightBalancedRhea 25245

2 pyruvate + H(+) = (2S)-2-acetolactate + CO2

Direction not assertedBalancedRhea 25249

aldehydo-N-acetyl-D-mannosamine + ATP = aldehydo-N-acetyl-D-mannosamine 6-phosphate + ADP + H(+)

Left to rightBalancedRhea 25253

N-acetyl-D-glucosamine 6-phosphate = aldehydo-N-acetyl-D-mannosamine 6-phosphate

Direction not assertedBalancedRhea 25257

2-hydroxyglutarate + FAD + H(+) = FADH2 + 2-oxoglutarate

Direction not assertedBalancedRhea 25261

2-phenylethylamine + O2 + H2O = 2-phenylacetaldehyde + H2O2 + NH4(+)

Left to rightBalancedRhea 25265

(R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 25269

UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + D-lysine + ATP = N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 25273

3',5'-cyclic AMP + H2O = AMP + H(+)

Left to rightBalancedRhea 25277

squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 25282

lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Left to rightBalance undeterminableRhea 25286

ethanol + NAD(+) = acetaldehyde + NADH + H(+)

Left to rightBalancedRhea 25290

acetaldehyde + NAD(+) + H2O = acetate + NADH + 2 H(+)

Left to rightBalancedRhea 25294

acetaldehyde + NADP(+) + H2O = acetate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 25298

7,8-dihydroneopterin 3'-triphosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)

Direction not assertedBalancedRhea 25302

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