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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

16,401–16,450 of 31,435, by identifier

5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + formate + ATP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate
Direction not assertedBalancedRhea 24836
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + CO + 5'-deoxyadenosine + formate + L-methionine + 3 H(+)
Direction not assertedBalancedRhea 24840
cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O = 2 isomaltose
Direction not assertedBalancedRhea 24844
3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O
Direction not assertedBalancedRhea 24848
pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose = pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP + H(+)
Direction not assertedBalancedRhea 24861
(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 = 4-O-deacetyl-16-O-demethylvindoline + succinate + CO2
Direction not asserted

Balanced

Rhea 24865

5'-deoxyadenosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + adenine

Direction not assertedBalancedRhea 24869

O-phospho-D-serine + H2O = D-serine + phosphate

Left to rightBalancedRhea 24873

L-sorbopyranose + A = 1-dehydro-L-sorbose + AH2

Direction not assertedBalancedRhea 24878

(S)-1-pyrroline-5-carboxylate + NADP(+) + 2 H2O = L-glutamate + NADPH + H(+)

Direction not assertedBalancedRhea 24882

5-hydroxyxanthotoxin + S-adenosyl-L-methionine = isopimpinellin + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 24894

2 GTP = 3',3'-c-di-GMP + 2 diphosphate

Direction not assertedBalancedRhea 24898

3',3'-c-di-GMP + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)

Direction not assertedBalancedRhea 24902

L-tyrosine = (E)-4-coumarate + NH4(+)

Direction not assertedBalancedRhea 24906

L,L-cystathionine = 2-aminobut-2-enoate + L-cysteine

Direction not assertedBalancedRhea 24910

L-homoserine = 2-aminobut-2-enoate + H2O

Direction not assertedBalancedRhea 24919

L-homoserine = 2-oxobutanoate + NH4(+)

Left to rightBalancedRhea 24923

L-cystine + H2O = S-sulfanyl-L-cysteine + pyruvate + NH4(+)

Direction not assertedBalancedRhea 24927

L-cysteine + H2O = hydrogen sulfide + pyruvate + NH4(+) + H(+)

Left to rightBalancedRhea 24931

imidazol-4-one + H2O = N-formimidoylglycine

Direction not assertedBalancedRhea 24935

(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + NADP(+) + 2 H2O = (4S)-4-hydroxy-L-glutamate + NADPH + H(+)

Direction not assertedBalancedRhea 24943

3-hydroxy-3-methylglutarate + malonyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + malonate

Direction not assertedBalancedRhea 24948

1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = N-acetyl-D-muramate 6-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 24952

N-acetyl-beta-D-muramate 6-phosphate + H2O = N-acetyl-beta-D-glucosamine 6-phosphate + (R)-lactate

Direction not assertedBalancedRhea 24956

apo-[aequorin] + coelenterazine + 3 Ca(2+) + O2 = excited state-[aequorin] + CO2

Direction not assertedBalance undeterminableRhea 24960

calcitriol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = calcitetrol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 24964

calcidiol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = secalciferol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 24968

calcitetrol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = (1S)-1,25-dihydroxy-24-oxocalciol + 2 oxidized [adrenodoxin] + 2 H2O

Left to rightBalance undeterminableRhea 24972

(1S)-1,25-dihydroxy-24-oxocalciol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = (1S)-1,23,25-trihydroxy-24-oxocalciol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 24976

3-hydroxy-4-methylanthranilate + ATP + H(+) = 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 24980

(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 oxidized [adrenodoxin] + 2 H2O

Left to rightBalance undeterminableRhea 24984

(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 reduced [adrenodoxin] + O2 + H(+) = calcitroate + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 24988

L-phenylalanine + reduced [NADPH--hemoprotein reductase] + O2 = N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 24992

N-hydroxy-L-phenylalanine + reduced [NADPH--hemoprotein reductase] + O2 = N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 24996

N,N-dihydroxy-L-phenylalanine + H(+) = (E)-phenylacetaldehyde oxime + CO2 + H2O

Direction not assertedBalancedRhea 25000

L-tryptophan + reduced [NADPH--hemoprotein reductase] + O2 = N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 25005

N-hydroxy-L-tryptophan + reduced [NADPH--hemoprotein reductase] + O2 = N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 25009

N,N-dihydroxy-L-tryptophan + H(+) = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O

Direction not assertedBalancedRhea 25013

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate

Left to rightBalance undeterminableRhea 25017

riboflavin + CTP = CDP + FMN + H(+)

Direction not assertedBalancedRhea 25021

S-methyl-5'-thioadenosine + H2O + H(+) = S-methyl-5'-thioinosine + NH4(+)

Direction not assertedBalancedRhea 25025

ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate

Direction not assertedBalancedRhea 25029

all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)

Right to leftBalancedRhea 25033

L-seryl-tRNA(Sec) + ATP = O-phospho-L-seryl-tRNA(Sec) + ADP

Direction not assertedBalancedRhea 25037

O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H2O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate

Direction not assertedBalancedRhea 25041

(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)

Direction not assertedBalancedRhea 25046

(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)

Direction not assertedBalancedRhea 25054

(E)-cinnamate + NADH + O2 + H(+) = (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)

Direction not assertedBalancedRhea 25058

3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + NADH + H(+)

Direction not assertedBalancedRhea 25062

(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H(+)

Direction not assertedBalancedRhea 25066

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