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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

16,351–16,400 of 31,435, by identifier

D-arabinose + ATP = D-arabinose 5-phosphate + ADP + H(+)
Direction not assertedBalancedRhea 24588
phosphoethanolamine + CTP + H(+) = CDP-ethanolamine + diphosphate
Left to rightBalancedRhea 24592
L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H(+)
Direction not assertedBalancedRhea 24596
sulfite + O2 + H2O = sulfate + H2O2
Left to rightBalancedRhea 24600
7-methylxanthine + S-adenosyl-L-methionine = theobromine + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 24604
5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO2 + H2O
Direction not assertedBalancedRhea 24608
17beta-estradiol + NAD(+) = estrone + NADH + H(+)

⇌ Reversible

Balanced

Rhea 24612

17beta-estradiol + NADP(+) = estrone + NADPH + H(+)

Right to leftBalancedRhea 24616

octan-1-ol + NAD(+) = octanal + NADH + H(+)

Direction not assertedBalancedRhea 24620

tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 24624

NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)

Direction not assertedBalancedRhea 24628

NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)

Direction not assertedBalancedRhea 24632

H2 + NAD(+) = NADH + H(+)

Direction not assertedBalancedRhea 24636

ergosteryl 3-beta-D-glucoside + H2O = ergosterol + D-glucose

Direction not assertedBalancedRhea 24640

L-arginine + NADPH + O2 + H(+) = N(omega)-hydroxy-L-arginine + NADP(+) + H2O

Direction not assertedBalancedRhea 24660

2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 = 2 L-citrulline + 2 nitric oxide + NADP(+) + 2 H2O + H(+)

Direction not assertedBalancedRhea 24664

hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)

Direction not assertedBalancedRhea 24670

cytidine + ATP = CMP + ADP + H(+)

Direction not assertedBalancedRhea 24674

5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O

Direction not assertedBalancedRhea 24678

5,10-methylenetetrahydromethanopterin + NADP(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH

Direction not assertedBalancedRhea 24682

N-formylmethanofuran + H2O = methanofuran + formate

Direction not assertedBalancedRhea 24686

eugenol + acetate + NADP(+) = (E)-coniferyl acetate + NADPH

Direction not assertedBalancedRhea 24690

(E)-isoeugenol + acetate + NADP(+) = (E)-coniferyl acetate + NADPH

Direction not assertedBalancedRhea 24694

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 24698

UDP-alpha-D-glucuronate + NAD(+) = UDP-beta-L-threo-pentopyranos-4-ulose + CO2 + NADH

Direction not assertedBalancedRhea 24702

UDP-4-amino-4-deoxy-beta-L-arabinose + (6R)-10-formyltetrahydrofolate = UDP-4-deoxy-4-formamido-beta-L-arabinose + (6S)-5,6,7,8-tetrahydrofolate + H(+)

Direction not assertedBalancedRhea 24706

UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate = UDP-beta-L-threo-pentopyranos-4-ulose + L-glutamate

Direction not assertedBalancedRhea 24710

L-methionyl(44)-[F-actin] + NADPH + O2 + H(+) = L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+) + H2O

Direction not assertedBalance undeterminableRhea 24722

N-demethylindolmycin + S-adenosyl-L-methionine = indolmycin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 24726

anthranilate + H(+) = aniline + CO2

Direction not assertedBalancedRhea 24730

4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde

Direction not assertedBalancedRhea 24734

(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H(+)

Direction not assertedBalancedRhea 24738

L-methionine = 2-aminobut-2-enoate + methanethiol

Direction not assertedBalancedRhea 24746

primary fluorescent chlorophyll catabolite + 2 oxidized [2Fe-2S]-[ferredoxin] = red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin] + 3 H(+)

Direction not assertedBalance undeterminableRhea 24752

L-dopa + NADH + H(+) = 3-(3,4-dihydroxyphenyl)propanoate + NH4(+) + NAD(+)

Direction not assertedBalancedRhea 24760

UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate

Direction not assertedBalancedRhea 24764

7(1)-hydroxychlorophyllide a + NAD(+) = chlorophyllide b + NADH + H(+)

Direction not assertedBalancedRhea 24768

7(1)-hydroxychlorophyllide a + NADP(+) = chlorophyllide b + NADPH + H(+)

Direction not assertedBalancedRhea 24772

pheophorbide a + H2O = C-13(2)-carboxypyropheophorbide a + methanol

Direction not assertedBalancedRhea 24776

C-13(2)-carboxypyropheophorbide a + H(+) = pyropheophorbide a + CO2

Direction not assertedBalancedRhea 24780

3-(3-hydroxyphenyl)propanoate + NADH + O2 + H(+) = 3-(2,3-dihydroxyphenyl)propanoate + NAD(+) + H2O

Direction not assertedBalancedRhea 24785

(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + succinate + H(+)

Direction not assertedBalancedRhea 24789

5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)

Direction not assertedBalancedRhea 24793

(S)-2,3,4,5-tetrahydrodipicolinate + H2O + H(+) = (S)-2-amino-6-oxoheptanedioate

Direction not assertedBalancedRhea 24797

L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

Left to rightBalancedRhea 24801

(2S)-2-acetolactate + thiamine diphosphate = 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate

Direction not assertedBalancedRhea 24805

(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O

Direction not assertedBalancedRhea 24809

L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate

Left to rightBalancedRhea 24813

dimethylallyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 24825

N(1)-(5-phospho-beta-D-ribosyl)glycinamide + formate + ATP = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 24829

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