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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Interactions
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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

16,301–16,350 of 31,435, by identifier

L-ornithine = L-proline + NH4(+)
Direction not assertedBalancedRhea 24368
N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + H2O = N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine + H(+)
Direction not assertedBalance undeterminableRhea 24372
apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + biotin + ATP = holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + AMP + diphosphate + H(+)
Left to rightBalance undeterminableRhea 24376
L-methionyl-tRNA(fMet) + (6R)-10-formyltetrahydrofolate = N-formyl-L-methionyl-tRNA(fMet) + (6S)-5,6,7,8-tetrahydrofolate + H(+)
Left to rightBalancedRhea 24380
deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)
Left to rightBalancedRhea 24384
uridine + phosphate = alpha-D-ribose 1-phosphate + uracil
Left to right

Balanced

Rhea 24388

dTDP-L-dihydrostreptose + streptidine 6-phosphate = O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP + H(+)

Direction not assertedBalancedRhea 24392

scytalone = 1,3,8-trihydroxynaphthalene + H2O

Direction not assertedBalancedRhea 24396

UMP + ATP = UDP + ADP

Direction not assertedBalancedRhea 24400

(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

Direction not assertedBalancedRhea 24404

adenosine + H2O + H(+) = inosine + NH4(+)

Left to rightBalancedRhea 24408

4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + NADH + H(+)

Direction not assertedBalancedRhea 24412

2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H(+)

Direction not assertedBalancedRhea 24416

N-terminal N-formyl-L-methionyl-[peptide] + H2O = N-terminal L-methionyl-[peptide] + formate

Direction not assertedBalance undeterminableRhea 24420

L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

Left to rightBalancedRhea 24424

oxaloacetate + H2O = oxalate + acetate + H(+)

Direction not assertedBalancedRhea 24432

methanophenazine + H2 = dihydromethanophenazine

Direction not assertedBalancedRhea 24436

phosphate(out) + ATP + H2O = ADP + 2 phosphate(in) + H(+)

Direction not assertedBalancedTransportRhea 24440

N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP-beta-L-fucose = N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + GDP + H(+)

Direction not assertedBalance undeterminableRhea 24444

enterobactin + UDP-alpha-D-glucose = monoglucosyl-enterobactin + UDP

Direction not assertedBalancedRhea 24448

L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 24452

alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate

Direction not assertedBalancedRhea 24456

malonyl-[ACP] + H(+) = acetyl-[ACP] + CO2

Direction not assertedBalance undeterminableRhea 24460

2-dehydro-3-deoxy-6-phospho-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate

Direction not assertedBalancedRhea 24464

N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O

Left to rightBalancedRhea 24468

maleimide + H2O = maleamate + H(+)

Direction not assertedBalancedRhea 24476

a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol

Direction not assertedBalance undeterminableRhea 24480

sulcatol + NAD(+) = sulcatone + NADH + H(+)

Direction not assertedBalancedRhea 24484

isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 24488

4-O-deacetylvindoline + acetyl-CoA = vindoline + CoA

Direction not assertedBalancedRhea 24496

adenosine 5'-tetraphosphate + H2O = phosphate + ATP + H(+)

Left to rightBalancedRhea 24500

1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)

Direction not assertedBalancedRhea 24504

prostaglandin F2alpha + NADP(+) = prostaglandin E2 + NADPH + H(+)

Right to leftBalancedRhea 24508

pyrazole + L-serine = 3-(pyrazol-1-yl)-L-alanine + H2O

Direction not assertedBalancedRhea 24512

gentamicin C1a + acetyl-CoA = N(2')-acetylgentamicin C1a + CoA + H(+)

Direction not assertedBalancedRhea 24516

L-saccharopine + NAD(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADH + H(+)

Left to rightBalancedRhea 24520

20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 5-O-beta-D-mycaminosyltylonolide + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 24524

(R)-lactaldehyde + NAD(+) = methylglyoxal + NADH + H(+)

Direction not assertedBalancedRhea 24528

L-tryptophan + O2 = N-formyl-L-kynurenine

Direction not assertedBalancedRhea 24536

D-glucose + A = D-glucono-1,5-lactone + AH2

Direction not assertedBalancedRhea 24540

L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)

Direction not assertedBalance undeterminableRhea 24544

an N(6)-acyl-L-lysine + H2O = a carboxylate + L-lysine

Direction not assertedBalance undeterminableRhea 24548

5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH + H(+)

Direction not assertedBalancedRhea 24552

5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + NADH + H(+)

Direction not assertedBalancedRhea 24556

L-serine + acetyl-CoA = O-acetyl-L-serine + CoA

Direction not assertedBalancedRhea 24560

a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate

Left to rightBalance undeterminableRhea 24564

a 6-phospho-beta-D-galactoside + H2O = D-galactose 6-phosphate + an alcohol

Direction not assertedBalance undeterminableRhea 24568

[(1->4)-alpha-D-glucosyl](n) + sucrose = [(1->4)-alpha-D-glucosyl](n+1) + D-fructose

Direction not assertedBalance undeterminableRhea 24572

diphosphate + H2O = 2 phosphate + H(+)

Left to rightBalancedRhea 24576

D-sorbitol 6-phosphate + H2O = D-sorbitol + phosphate

Direction not assertedBalancedRhea 24580

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