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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

16,251–16,300 of 31,435, by identifier

2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP
Direction not assertedBalancedRhea 24156
D-galactose + O2 = D-galacto-hexodialdose + H2O2
Direction not assertedBalancedRhea 24160
L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol
Direction not assertedBalance undeterminableRhea 24164
3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)
Direction not assertedBalance undeterminableRhea 24168
a 3-oxo-5beta-steroid + A = a 3-oxo-Delta(4)-steroid + AH2
Direction not assertedBalance undeterminableRhea 24172
[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + ATP + H(+) = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + 2 oxidized [2Fe-2S]-[ferredoxin] + AMP + diphosphate

? Direction not asserted

Balance undeterminable

Rhea 24176

2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)

Left to rightBalance undeterminableRhea 24180

4,5-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2

Direction not assertedBalancedRhea 24184

cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + NADH + H(+)

Direction not assertedBalancedRhea 24188

(2R,4S)-2,4-diaminopentanoate + NADP(+) + H2O = (2R)-2-amino-4-oxopentanoate + NH4(+) + NADPH + H(+)

Direction not assertedBalancedRhea 24192

(2R,4S)-2,4-diaminopentanoate + NAD(+) + H2O = (2R)-2-amino-4-oxopentanoate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 24196

4-aminobenzoate + H(+) = aniline + CO2

Direction not assertedBalancedRhea 24200

acetyl phosphate + sulfite + H(+) = sulfoacetaldehyde + phosphate

Direction not assertedBalancedRhea 24204

1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + NADPH + H(+)

Direction not assertedBalancedRhea 24208

5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)

Direction not assertedBalancedRhea 24212

(2E,6E)-farnesal + NAD(+) + H2O = (2E,6E)-farnesoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 24216

beta-myrcene + reduced [NADPH--hemoprotein reductase] + O2 = (4R)-ipsdienol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 24220

(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) = 4-methylcatechol + CO2 + NADPH

Direction not assertedBalancedRhea 24224

(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) = 4-methylcatechol + CO2 + NADH

Direction not assertedBalancedRhea 24228

2-dehydro-3-deoxy-D-gluconate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + NADH + H(+)

Direction not assertedBalancedRhea 24232

trimethylamine + 2 Fe(III)-[cytochrome c] + H2O = trimethylamine N-oxide + 2 Fe(II)-[cytochrome c] + 3 H(+)

Direction not assertedBalance undeterminableRhea 24236

sulfite + A + AMP + 2 H(+) = adenosine 5'-phosphosulfate + AH2

Direction not assertedBalancedRhea 24240

pseudotropine + NADP(+) = tropinone + NADPH + H(+)

Direction not assertedBalancedRhea 24244

glyoxylate + L-alanine = glycine + pyruvate

Left to rightBalancedRhea 24248

P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP + 2 H(+)

Direction not assertedBalancedRhea 24252

kanamycin A + ATP = kanamycin 3'-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 24256

(3E)-2-oxohex-3-enedioate + H(+) = 2-oxopent-4-enoate + CO2

Direction not assertedBalancedRhea 24260

D-xylulose 5-phosphate + formaldehyde = dihydroxyacetone + D-glyceraldehyde 3-phosphate

Direction not assertedBalancedRhea 24264

2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + NADPH + H(+)

Direction not assertedBalancedRhea 24268

Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 + H(+) = Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+) + H2O

Direction not assertedBalancedRhea 24272

acetate + diphosphate = acetyl phosphate + phosphate

Direction not assertedBalancedRhea 24276

L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)

Direction not assertedBalancedRhea 24284

5-formimidoyltetrahydrofolate + glycine = N-formimidoylglycine + (6S)-5,6,7,8-tetrahydrofolate

Direction not assertedBalancedRhea 24288

L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)

Direction not assertedBalancedRhea 24292

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H(+)

Direction not assertedBalancedRhea 24296

2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH2

Direction not assertedBalancedRhea 24300

N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2

Direction not assertedBalance undeterminableRhea 24304

25-hydroxycholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 7alpha,25-dihydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 24308

L-lysyl-[cytochrome c] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 24312

(2E,6E,10E)-geranylgeranyl diphosphate = (+)-copalyl diphosphate

Direction not assertedBalancedRhea 24316

an L-polyhomomethionine + reduced [NADPH--hemoprotein reductase] + O2 = an L-N-hydroxypolyhomomethionine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 24320

6-oxocineole + NADPH + O2 + H(+) = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + NADP(+) + H2O

Direction not assertedBalancedRhea 24324

7,8-dihydrofolate + formate + ATP = 10-formyldihydrofolate + ADP + phosphate

Direction not assertedBalancedRhea 24328

3alpha-hydroxy-3,5-dihydromonacolin L carboxylate = monacolin L carboxylate + H2O

Direction not assertedBalancedRhea 24332

a carboxylate + ATP + CoA = an acyl-CoA + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 24336

(R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + NADH + H(+)

Direction not assertedBalancedRhea 24340

ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + NADPH + H(+)

Direction not assertedBalancedRhea 24352

a 1-acyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine

Direction not assertedBalance undeterminableRhea 24356

siroheme + 2 H(+) = sirohydrochlorin + Fe(2+)

Direction not assertedBalancedRhea 24360

N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + nicotinamide + L-lysyl-[protein]

Direction not assertedBalance undeterminableRhea 24364

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