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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

15,501–15,550 of 31,435, by identifier

L-asparagine + H2O = L-aspartate + NH4(+)
Left to rightBalancedRhea 21016
5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate
Direction not assertedBalancedRhea 21020
glyoxylate + NADP(+) + CoA = oxalyl-CoA + NADPH + H(+)
Direction not assertedBalancedRhea 21024
an N-terminal L-alpha-aminoacyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein] + CoA + H(+)
Direction not assertedBalance undeterminableRhea 21028
glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)
Left to rightBalance undeterminableRhea 21032
2 acetyl-CoA = acetoacetyl-CoA + CoA
ReversibleBalancedRhea 21036
CO + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + 2 H(+)

Direction not assertedBalance undeterminableRhea 21040

24-methylidenelophenol + S-adenosyl-L-methionine = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 21044

isopropylamine + L-glutamate + ATP = gamma-L-glutamyl-isopropylamide + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 21048

(S)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + NADH + H(+)

Direction not assertedBalancedRhea 21052

3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA

Direction not assertedBalancedRhea 21060

[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide

ReversibleBalance undeterminableRhea 21064

nitrite + A + H2O = nitrate + AH2

Direction not assertedBalancedRhea 21068

2'-deoxyuridine + 2-oxoglutarate + O2 = uridine + succinate + CO2

Direction not assertedBalancedRhea 21076

L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate

Direction not assertedBalancedRhea 21080

chondroitin 4'-sulfate = dermatan 4'-sulfate

Direction not assertedBalance undeterminableRhea 21084

a (2R,3R)-dihydroflavonol + 2-oxoglutarate + O2 = a flavonol + succinate + CO2 + H2O

Direction not assertedBalance undeterminableRhea 21088

12-hydroxydihydrochelirubine + S-adenosyl-L-methionine = dihydromacarpine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 21092

3-dehydroquinate = 3-dehydroshikimate + H2O

Direction not assertedBalancedRhea 21096

cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

Left to rightBalancedRhea 21104

(S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO2

Direction not assertedBalancedRhea 21108

a globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose

Left to rightBalance undeterminableRhea 21112

D-maltose + phosphate = beta-D-glucose 1-phosphate + D-glucose

Direction not assertedBalancedRhea 21116

cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Thr) + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 21124

zymosterol + S-adenosyl-L-methionine = fecosterol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 21128

xanthine + O2 + H2O = urate + H2O2

Direction not assertedBalancedRhea 21132

(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA

Left to rightBalancedRhea 21136

inosine + ATP = IMP + ADP + H(+)

Direction not assertedBalancedRhea 21140

5-methyl-5,6,7,8-tetrahydromethanopterin + oxidized coenzyme F420-(gamma-L-Glu)(n) + H(+) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)

Direction not assertedBalance undeterminableRhea 21144

indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + UDP + H(+)

Direction not assertedBalancedRhea 21148

trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline

Direction not assertedBalancedRhea 21152

(2R)-2-phosphoglycerate + H2O = (R)-glycerate + phosphate

Direction not assertedBalancedRhea 21156

oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA

Right to leftBalancedRhea 21160

a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)

Direction not assertedBalance undeterminableRhea 21164

L-idonate + NAD(+) = 5-dehydro-D-gluconate + NADH + H(+)

Direction not assertedBalancedRhea 21172

L-idonate + NADP(+) = 5-dehydro-D-gluconate + NADPH + H(+)

Direction not assertedBalancedRhea 21176

1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = indole-3-acetyl-1D-myo-inositol + D-glucose

Direction not assertedBalancedRhea 21180

a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP

Left to rightBalance undeterminableRhea 21184

deamido-NAD(+) + NH4(+) + ATP = AMP + diphosphate + NAD(+) + H(+)

Direction not assertedBalancedRhea 21188

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine

Direction not assertedBalancedRhea 21196

L-lysine + 2-oxoglutarate = (S)-2-amino-6-oxohexanoate + L-glutamate

Direction not assertedBalancedRhea 21200

a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine

Direction not assertedBalance undeterminableRhea 21204

O-phospho-L-serine + H2O = L-serine + phosphate

Left to rightBalancedRhea 21208

N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] + H2O = 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate

Direction not assertedBalance undeterminableRhea 21212

D-ribose 5-phosphate + ATP = alpha-D-ribose 1,5-bisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 21216

L-dopa + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)

Direction not assertedBalancedRhea 21220

CDP-choline + sphing-4-enine = sphing-4-enine-phosphocholine + CMP + H(+)

Direction not assertedBalancedRhea 21224

alpha-maltose = beta-maltose

Direction not assertedBalancedRhea 21228

L-histidine = trans-urocanate + NH4(+)

Direction not assertedBalancedRhea 21232

anthranilate + NADPH + O2 + 2 H(+) = 2,3-dihydroxybenzoate + NH4(+) + NADP(+)

Direction not assertedBalancedRhea 21236

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