Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

15,451–15,500 of 31,435, by identifier

2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)
Left to rightBalancedRhea 20804
(3S)-citryl-CoA = oxaloacetate + acetyl-CoA
Direction not assertedBalancedRhea 20812
3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + NADPH + H(+)
Direction not assertedBalancedRhea 20816
choline sulfate + H2O = choline + sulfate + H(+)
Direction not assertedBalancedRhea 20820
adenosine + ATP = AMP + ADP + H(+)
Left to rightBalancedRhea 20824
a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2
Left to rightBalance undeterminableRhea 20828
guanine(out) + ATP + H2O = guanine(in) + ADP + phosphate + H(+)

? Direction not asserted

Balanced

Transport

Rhea 20832

L-histidine + H(+) = histamine + CO2

Direction not assertedBalancedRhea 20840

hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)

Left to rightBalancedRhea 20844

pyruvate + phosphate + O2 + H(+) = acetyl phosphate + H2O2 + CO2

Direction not assertedBalancedRhea 20848

ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)

Direction not assertedBalancedTransportRhea 20852

an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid

Left to rightBalance undeterminableRhea 20856

(1S,6R)-isopiperitenol + NAD(+) = (6R)-isopiperitenone + NADH + H(+)

Direction not assertedBalancedRhea 20860

alpha,alpha-trehalose 6-phosphate + phosphate = beta-D-glucose 1-phosphate + D-glucose 6-phosphate

Direction not assertedBalancedRhea 20864

(20S)-ginsenoside Rd + UDP-alpha-D-glucose = (20S)-ginsenoside Rb1 + UDP + H(+)

Direction not assertedBalancedRhea 20872

(R)-2-benzylsuccinyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]

Direction not assertedBalance undeterminableRhea 20876

10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + NADH + H(+)

Left to rightBalancedRhea 20880

L-serine + NAD(+) + H2O = 3-hydroxypyruvate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 20884

3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)

Direction not assertedBalancedRhea 20888

butanoyl-CoA + phosphate = butanoyl phosphate + CoA

Direction not assertedBalancedRhea 20892

urea + hydrogencarbonate + ATP = urea-1-carboxylate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 20896

N-benzyloxycarbonylglycine + H2O + H(+) = benzyl alcohol + glycine + CO2

Direction not assertedBalancedRhea 20900

(S)-2-hydroxypropyl-coenzyme M = (S)-1,2-epoxypropane + coenzyme M

Direction not assertedBalancedRhea 20904

3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP + H(+)

Left to rightBalance undeterminableRhea 20908

(2E,6E,10E)-geranylgeranyl diphosphate = taxa-4(5),11(12)-diene + diphosphate

Direction not assertedBalancedRhea 20912

sulfite + L-cysteine = L-cysteate + hydrogen sulfide

Direction not assertedBalancedRhea 20916

2,4-dichlorophenol + NADPH + O2 + H(+) = 3,5-dichlorocatechol + NADP(+) + H2O

Direction not assertedBalancedRhea 20920

a [peptide]-C-terminal (2S)-2-hydroxyglycine = a [peptide]-C-terminal amide + glyoxylate

Direction not assertedBalance undeterminableRhea 20924

[DsbA protein]-dithiol + a quinone = [DsbA protein]-disulfide + a quinol

Direction not assertedBalance undeterminableRhea 20928

L-erythrulose 1-phosphate = dihydroxyacetone phosphate + formaldehyde

Direction not assertedBalancedRhea 20932

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O

Direction not assertedBalancedRhea 20936

1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)

ReversibleBalancedRhea 20940

theobromine + S-adenosyl-L-methionine = caffeine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 20944

3-sulfopyruvate + H(+) = sulfoacetaldehyde + CO2

Direction not assertedBalancedRhea 20948

N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP + H(+)

Direction not assertedBalancedRhea 20952

2-phenylacetate + ATP + CoA = phenylacetyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 20956

1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate

Left to rightBalancedRhea 20960

L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate

Direction not assertedBalancedRhea 20964

L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O

Direction not assertedBalancedRhea 20968

a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine = a 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + a 1-O-alkyl-sn-glycero-3-phosphocholine

Direction not assertedBalance undeterminableRhea 20972

a primary nitroalkane + O2 + H2O = an aldehyde + nitrite + H2O2 + H(+)

Direction not assertedBalance undeterminableRhea 20976

2 (4Z,15Z)-bilirubin IXalpha + O2 = 2 biliverdin IXalpha + 2 H2O

Direction not assertedBalancedRhea 20980

a sphingomyelin + H2O = an N-acylsphing-4-enine 1-phosphate + choline + H(+)

Direction not assertedBalance undeterminableRhea 20984

ATP + 2 H2O = AMP + 2 phosphate + 2 H(+)

Left to rightBalancedRhea 20988

16-hydroxytabersonine + S-adenosyl-L-methionine = 16-methoxytabersonine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 20992

(2Z,4E)-2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH4(+)

Direction not assertedBalancedRhea 20996

1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene

Direction not assertedBalancedRhea 21000

(R)-pantolactone + A = 2-dehydropantolactone + AH2

Direction not assertedBalancedRhea 21004

diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + NADPH + H(+)

Direction not assertedBalancedRhea 21008

4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP + n H(+)

Direction not assertedBalance undeterminableRhea 21012

Page 310 of 629