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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

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Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

15,551–15,600 of 31,435, by identifier

geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate
Direction not assertedBalance undeterminableRhea 21240
an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine = an 8-methoxyfurocoumarin + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalance undeterminableRhea 21244
RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
ReversibleBalance undeterminableRhea 21248
(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
Direction not assertedBalancedRhea 21252
3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate
Direction not assertedBalancedRhea 21256
[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol
Direction not assertedBalance undeterminableRhea 21260

glycolate + A = glyoxylate + AH2

Direction not assertedBalancedRhea 21264

(R)-canadine + 2 NADP(+) = berberine + 2 NADPH + H(+)

Direction not assertedBalancedRhea 21268

spermidine + glutathione + ATP = glutathionylspermidine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 21272

D-arabinitol + NADP(+) = D-xylulose + NADPH + H(+)

Direction not assertedBalancedRhea 21276

thiamine + 2 O2 + H2O = thiamine acetate + 2 H2O2 + H(+)

Direction not assertedBalancedRhea 21280

all-trans-retinol + NAD(+) = all-trans-retinal + NADH + H(+)

Left to rightBalancedRhea 21284

sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol

Direction not assertedBalancedRhea 21288

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)

Left to rightBalance undeterminableRhea 21292

D-galactose + NAD(+) = D-galactono-1,4-lactone + NADH + H(+)

Direction not assertedBalancedRhea 21296

an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + H2O = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + sulfate + H(+)

Left to rightBalance undeterminableRhea 21300

ent-kaur-16-en-19-ol + reduced [NADPH--hemoprotein reductase] + O2 = ent-kaur-16-en-19-al + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 21304

(S)-2,3-epoxysqualene = cycloartenol

Direction not assertedBalancedRhea 21308

2,5-dihydroxybenzoate + H(+) = hydroquinone + CO2

Direction not assertedBalancedRhea 21312

phorbol 12,13-dibutanoate + H2O = phorbol 13-butanoate + butanoate + H(+)

Direction not assertedBalancedRhea 21316

D-sorbitol + A = keto-L-sorbose + AH2

Direction not assertedBalancedRhea 21320

reduced [rubredoxin] + superoxide + 2 H(+) = oxidized [rubredoxin] + H2O2

Direction not assertedBalance undeterminableRhea 21324

D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H(+)

Direction not assertedBalancedRhea 21332

pyridoxal + NAD(+) = 4-pyridoxolactone + NADH + H(+)

Direction not assertedBalancedRhea 21336

1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin

Direction not assertedBalancedRhea 21340

10 malonyl-CoA + 8 H(+) = tetracenomycin F2 + 10 CO2 + 10 CoA + 2 H2O

Direction not assertedBalancedRhea 21348

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)

Direction not assertedBalancedRhea 21352

L-arabinitol + NAD(+) = L-ribulose + NADH + H(+)

Direction not assertedBalancedRhea 21356

beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)

ReversibleBalancedRhea 21360

N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate

Direction not assertedBalancedRhea 21364

urate + O2 + H2O = 5-hydroxyisourate + H2O2

Direction not assertedBalancedRhea 21368

urethane + H2O + H(+) = ethanol + NH4(+) + CO2

Direction not assertedBalancedRhea 21372

3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2

Left to rightBalancedRhea 21376

3,7,11,15-tetramethylhexadecanoate + ATP + CoA = phytanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 21380

L-phenylalanine = (E)-cinnamate + NH4(+)

Direction not assertedBalancedRhea 21384

L-2-aminohexano-6-lactam + H2O = L-lysine

Direction not assertedBalancedRhea 21388

2-phenylacetaldehyde + NAD(+) + H2O = 2-phenylacetate + NADH + 2 H(+)

Direction not assertedBalancedRhea 21392

(S)-methylmalonyl-CoA + Na(+)(in) + H(+)(out) = propanoyl-CoA + Na(+)(out) + CO2

Direction not assertedBalancedTransportRhea 21396

chloride + O2 = chlorite

Direction not assertedBalancedRhea 21404

L-phenylalanine + NAD(+) + H2O = 3-phenylpyruvate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 21408

sn-glycerol 1-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)

Direction not assertedBalancedRhea 21412

sn-glycerol 1-phosphate + NADP(+) = dihydroxyacetone phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 21416

prostaglandin I2 + NADP(+) = 15-dehydro-prostaglandin I2 + NADPH + H(+)

Direction not assertedBalancedRhea 21420

3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H(+)

Direction not assertedBalancedRhea 21424

(2R)-3-sulfolactate = sulfite + pyruvate + H(+)

Direction not assertedBalancedRhea 21428

(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)

ReversibleBalancedRhea 21432

[translation elongation factor 2] + ATP = [translation elongation factor 2]-phosphate + ADP + H(+)

Direction not assertedBalance undeterminableRhea 21436

a long-chain fatty aldehyde + 2 NADPH + O2 + H(+) = a long-chain alkane + formate + 2 NADP(+) + H2O

Direction not assertedBalance undeterminableRhea 21440

3-(2-hydroxyphenyl)propanoate + NAD(+) = trans-2-coumarate + NADH + H(+)

Direction not assertedBalancedRhea 21444

N2 + 8 reduced [2Fe-2S]-[ferredoxin] + 16 ATP + 16 H2O = H2 + 8 oxidized [2Fe-2S]-[ferredoxin] + 2 NH4(+) + 16 ADP + 16 phosphate + 6 H(+)

Direction not assertedBalance undeterminableRhea 21448

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