Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

14,401–14,450 of 31,435, by identifier

juvenile hormone II + H2O = juvenile hormone II carboxylate + methanol + H(+)
Direction not assertedBalancedRhea 16393
2 D-glucopyranose 1-phosphate = D-glucose 1,6-bisphosphate + D-glucose
Direction not assertedBalancedRhea 16397
benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + NADPH + H(+)
Direction not assertedBalancedRhea 16405
(2R)-1,2-dihydrovomilenine + NADP(+) = vomilenine + NADPH + H(+)
Direction not assertedBalancedRhea 16409
N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] = L-lysyl-[glycine-cleavage complex H protein] + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]
Left to rightBalance undeterminableRhea 16413
(S)-1-pyrroline-5-carboxylate + NAD(+) + 2 H2O = L-glutamate + NADH + H(+)
Direction not assertedBalancedRhea 16417

an aldehyde + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = a carboxylate + 2 reduced [2Fe-2S]-[ferredoxin] + 3 H(+)

Direction not assertedBalance undeterminableRhea 16421

formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)

Direction not assertedBalancedRhea 16425

UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 16429

RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

Left to rightBalance undeterminableRhea 16437

L-glutaminyl-[protein] + H2O = L-glutamyl-[protein] + NH4(+)

Left to rightBalance undeterminableRhea 16441

(2R,3S)-2,4',7-trihydroxyisoflavanone = daidzein + H2O + H(+)

Direction not assertedBalancedRhea 16445

kanamycin B + acetyl-CoA = N(6')-acetylkanamycin B + CoA + H(+)

Direction not assertedBalancedRhea 16449

(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O = 2-formylbenzoate + pyruvate

Direction not assertedBalancedRhea 16453

(2R,3S)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + NADH + H(+)

Direction not assertedBalancedRhea 16457

urate(in) + ATP + H2O = urate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 16461

2 Fe(III)-[cytochrome c553] + (R)-lactate = 2 Fe(II)-[cytochrome c553] + pyruvate + 2 H(+)

Direction not assertedBalance undeterminableRhea 16465

(R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate

Direction not assertedBalancedRhea 16469

cyclohexane-1,3-dione + H2O = 5-oxohexanoate + H(+)

Direction not assertedBalancedRhea 16473

prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)

Left to rightBalancedRhea 16477

3 S-adenosyl-L-methionine = nicotianamine + 3 S-methyl-5'-thioadenosine + 3 H(+)

Direction not assertedBalancedRhea 16481

imidazole-4-acetate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + phosphate + diphosphate + H(+)

Direction not assertedBalancedRhea 16485

(R)-prunasin + H2O = mandelonitrile + D-glucose

Direction not assertedBalancedRhea 16489

glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H(+)

Direction not assertedBalancedRhea 16493

adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine = N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 16497

sn-glycero-3-phospho-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate + H(+)

Left to rightBalancedRhea 16501

chorismate = 4-hydroxybenzoate + pyruvate

Direction not assertedBalancedRhea 16505

oxalate + H(+) = formate + CO2

Direction not assertedBalancedRhea 16509

(S)-lactate + O2 = acetate + CO2 + H2O

Direction not assertedBalancedRhea 16513

(R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + NADH + H(+)

Direction not assertedBalancedRhea 16517

2 reduced [2Fe-2S]-[ferredoxin] + NAD(+) + H(+) = 2 oxidized [2Fe-2S]-[ferredoxin] + NADH

Direction not assertedBalance undeterminableRhea 16521

2-dehydro-3-deoxy-D-galactonate + ATP = 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)

Direction not assertedBalancedRhea 16525

sulfate + ADP + H(+) = adenosine 5'-phosphosulfate + phosphate

Direction not assertedBalancedRhea 16529

L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 16533

(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate

Direction not assertedBalancedRhea 16537

9-cis-violaxanthin + O2 = (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin

Direction not assertedBalancedRhea 16541

formyl-CoA + oxalate = oxalyl-CoA + formate

Direction not assertedBalancedRhea 16545

aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] = N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] + H2O

Direction not assertedBalance undeterminableRhea 16553

(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO2

Left to rightBalancedRhea 16557

squalene + H2O = hopan-22-ol

Direction not assertedBalancedRhea 16561

L-histidine + 2-oxoglutarate = 3-(imidazol-5-yl)pyruvate + L-glutamate

Direction not assertedBalancedRhea 16565

L-lysyl-[collagen] + 2-oxoglutarate + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + succinate + CO2

Direction not assertedBalance undeterminableRhea 16569

4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate

Direction not assertedBalancedRhea 16573

ADP + ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate

Direction not assertedBalancedRhea 16577

2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O

Direction not assertedBalance undeterminableRhea 16581

[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]

Direction not assertedBalance undeterminableRhea 16585

sucrose + A = 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2

Direction not assertedBalancedRhea 16589

3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 16593

UTP + NH4(+) + ATP = CTP + ADP + phosphate + 2 H(+)

Direction not assertedBalancedRhea 16597

L-aspartate = fumarate + NH4(+)

Direction not assertedBalancedRhea 16601

Page 289 of 629