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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Interactions
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Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

14,451–14,500 of 31,435, by identifier

dodecanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)
Direction not assertedBalancedRhea 16605
AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine
Direction not assertedBalancedRhea 16609
an arylamine + acetyl-CoA = an N-acetylarylamine + CoA
Direction not assertedBalance undeterminableRhea 16613
beta-D-glucosyl-(1->3)-D-glucose + phosphate = alpha-D-glucose 1-phosphate + D-glucose
Direction not assertedBalancedRhea 16617
dihydrosanguinarine + O2 + H(+) = sanguinarine + H2O2
Direction not assertedBalancedRhea 16621
hydrogen sulfide + acetyl-CoA = thioacetate + CoA
Direction not assertedBalancedRhea 16625
(S)-malyl-CoA = glyoxylate + acetyl-CoA

Direction not assertedBalancedRhea 16629

guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine

Direction not assertedBalancedRhea 16633

[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)

Direction not assertedBalance undeterminableRhea 16637

a long-chain fatty acyl ethyl ester + H2O = a long-chain fatty acid + ethanol + H(+)

Direction not assertedBalance undeterminableRhea 16641

hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)

Left to rightBalancedRhea 16645

(S)-N-methylcoclaurine + reduced [NADPH--hemoprotein reductase] + O2 = (S)-3'-hydroxy-N-methylcoclaurine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 16649

D-gluconate + NADP(+) = 2-dehydro-D-gluconate + NADPH + H(+)

Direction not assertedBalancedRhea 16653

inosine + H2O = hypoxanthine + D-ribose

Direction not assertedBalancedRhea 16657

fluoride + S-adenosyl-L-methionine = 5'-deoxy-5'-fluoroadenosine + L-methionine

Direction not assertedBalancedRhea 16661

(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate

Direction not assertedBalancedRhea 16665

xanthine + NAD(+) + H2O = urate + NADH + H(+)

Direction not assertedBalancedRhea 16669

3-phosphonopyruvate + H2O = pyruvate + phosphate + H(+)

Direction not assertedBalancedRhea 16673

fluoroacetaldehyde + NAD(+) + H2O = fluoroacetate + NADH + 2 H(+)

Direction not assertedBalancedRhea 16677

a di-trans,poly-cis-dolichol + hexadecanoyl-CoA = a di-trans,poly-cis-dolichyl hexadecanoate + CoA

Direction not assertedBalance undeterminableRhea 16685

D-glucose 6-phosphate + H2O = D-glucose + phosphate

Left to rightBalancedRhea 16689

alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal

Direction not assertedBalancedRhea 16693

quinaldate + A + H2O = kynurenate + AH2

Direction not assertedBalancedRhea 16697

17alpha-estradiol + NAD(+) = estrone + NADH + H(+)

Direction not assertedBalancedRhea 16701

17alpha-estradiol + NADP(+) = estrone + NADPH + H(+)

Right to leftBalancedRhea 16705

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

Direction not assertedBalancedRhea 16709

S-succinylglutathione + H2O = glutathione + succinate + H(+)

Direction not assertedBalancedRhea 16713

deoxycholate + FAD + H2O + H(+) = cholate + FADH2

Direction not assertedBalancedRhea 16717

5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 H(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)

Direction not assertedBalance undeterminableRhea 16721

a phosphatidylglycerol phosphate + H2O = a phosphatidylglycerol + phosphate

Direction not assertedBalance undeterminableRhea 16725

(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH + H(+)

Direction not assertedBalancedRhea 16729

orsellinate + H(+) = orcinol + CO2

Direction not assertedBalancedRhea 16733

toluene + NADH + O2 + H(+) = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)

Direction not assertedBalancedRhea 16737

a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

Left to rightBalance undeterminableRhea 16741

phylloquinone + AH2 + O2 = 2,3-epoxyphylloquinone + A + H2O

Direction not assertedBalancedRhea 16745

phosphonoacetate + H2O = acetate + phosphate + H(+)

Direction not assertedBalancedRhea 16749

Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 = 3,8-divinyl protochlorophyllide a + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 16753

trypanothione + NADP(+) = trypanothione disulfide + NADPH + H(+)

Direction not assertedBalancedRhea 16757

chlorohydroquinone + O2 = 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)

Direction not assertedBalancedRhea 16761

D-mannitol + NADP(+) = D-fructose + NADPH + H(+)

Direction not assertedBalancedRhea 16765

(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + (2R)-3-phosphoglycerate + H(+)

Left to rightBalancedRhea 16769

a ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GM1 (d18:1(4E)) + UDP + H(+)

Left to rightBalance undeterminableRhea 16773

K(+)(out) + ATP + H2O = K(+)(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 16777

a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)

Left to rightBalance undeterminableRhea 16781

an adenosine in tRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 16785

a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2

Left to rightBalance undeterminableRhea 16789

N-[(R)-4-phosphopantothenoyl]-L-cysteine + H(+) = (R)-4'-phosphopantetheine + CO2

Left to rightBalancedRhea 16793

L-tyrosyl-[protein] + 3'-phosphoadenylyl sulfate = O-sulfo-L-tyrosine-[protein] + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalance undeterminableRhea 16801

deacetoxycephalosporin C + 2-oxoglutarate + O2 = deacetylcephalosporin C + succinate + CO2

Direction not assertedBalancedRhea 16805

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate

Direction not assertedBalancedRhea 16809

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