Proteins/UNIPROT:P41587

VIPR2

ProteinUNIPROT:P41587

G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of potency PACAP38 = VIP > PACAP27. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May be coupled to phospholipase C..

Function from UniProtKB (P41587), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 3 reference databases · Subject: VIPR2 · Sources: Hetionet, Reactome, WikiPathways

Order

VIPR2 covaries with ANK2ProteinHetionet hetionet:covaries:287-7434Inferred only
VIPR2 covaries with C19orf12ProteinHetionet hetionet:covaries:7434-83636Inferred only
VIPR2 covaries with CSTBProteinHetionet hetionet:covaries:1476-7434Inferred only
VIPR2 covaries with PTPRN2ProteinHetionet hetionet:covaries:5799-7434Inferred only
VIPR2 covaries with RYR2ProteinHetionet hetionet:covaries:6262-7434Inferred only
APP interacts with VIPR2ProteinHetionet hetionet:interacts:351-7434Inferred only
VIP interacts with VIPR2ProteinHetionet hetionet:interacts:7432-7434Inferred only
VIPR2 participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
VIPR2 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
VIPR2 participates in Glucagon-type ligand receptorsPathwayReactome R-HSA-420092Inferred only
VIPR2 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
VIPR2 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only

Show the remaining 4

VIPR2 participates in GPCRs class B secretin likePathwayWikiPathways WP334Inferred only
VIPR2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
VIPR2 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
VIPR2 participates in Sudden infant death syndrome SIDS susceptibility pathwaysPathwayWikiPathways WP706Inferred only

Other names

9 names

Resolves to: VIPR2

Also called: Helodermin-preferring VIP receptorPACAP type III receptorPACAP-R-3PACAP-R3Pituitary adenylate cyclase-activating polypeptide type III receptorVIP-R-2VIP2RVPAC2 receptorVPAC2R

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