Proteins/UNIPROT:Q7Z4G4

TRMT11

ProteinUNIPROT:Q7Z4G4tRNA

Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases..

Function from UniProtKB (Q7Z4G4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 3 reference databases · Subject: TRMT11 · Sources: Bgee, Hetionet, Reactome

Order

TRMT11 covaries with CTRB1ProteinHetionet hetionet:covaries:1504-60487Inferred only
TRMT11 is expressed in secondary oocyteCell typeBgee ENSG00000066651Inferred only
TRMT11 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
TRMT11 participates in tRNA modification in the nucleus and cytosolPathwayReactome R-HSA-6782315Inferred only
TRMT11 participates in tRNA processingPathwayReactome R-HSA-72306Inferred only
HDAC2 decreases the expression of TRMT11ProteinHetionet hetionet:regulates:3066-60487Inferred only
PCMT1 decreases the expression of TRMT11ProteinHetionet hetionet:regulates:5110-60487Inferred only
POLR2K increases the expression of TRMT11ProteinHetionet hetionet:regulates:5440-60487Inferred only
SOX3 decreases the expression of TRMT11ProteinHetionet hetionet:regulates:6658-60487Inferred only

Reactions

2 reactions

proton+CHEBI:16680+MAM03061cS-adenosyl-L-methionine+MAM03084c
Catalysed by TRMT11 or TRMT1
Reaction pageReversibleBalance undeterminableEC 2.1.1.214, 2.1.1.215, 2.1.1.216cytosol
Human-GEM MAR09519CC BY 4.0Reference data
CHEBI:74269+S-adenosyl-L-methionineCHEBI:74481+S-adenosyl-L-homocysteine+hydron
Catalysed by TRMT11

Other names

3 names

Resolves to: TRMT11

Also called: C6orf75guanine(10)-N(2)tRNA methyltransferase 11 homolog

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