Proteins/UNIPROT:Q9NXH9

TRMT1

ProteinUNIPROT:Q9NXH9tRNA

Dimethylates a single guanine residue at position 26 of most nuclear- and mitochondrial-encoded tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. tRNA guanine(26)-dimethylation is required for redox homeostasis and ensure proper cellular proliferation and oxidative stress survival..

Function from UniProtKB (Q9NXH9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

complex neurodevelopmental disorder has a germline basis in TRMT1DiseaseGenCC HGNC:25980|MONDO:0100038Inferred only
intellectual developmental disorder, autosomal recessive 68 has a germline basis in TRMT1DiseaseGenCC HGNC:25980|MONDO:0032665Inferred only
syndromic intellectual disability has a germline basis in TRMT1DiseaseGenCC HGNC:25980|MONDO:0000508Inferred only

Statements

24 statements

24 statements · 3 reference databases · Subject: TRMT1 · Sources: Hetionet, Reactome, WikiPathways

Order

MTERF1 covaries with TRMT1ProteinHetionet hetionet:covaries:55621-7978Inferred only
NRSN2 covaries with TRMT1ProteinHetionet hetionet:covaries:55621-80023Inferred only
MAGEA11 interacts with TRMT1ProteinHetionet hetionet:interacts:4110-55621Inferred only
TERF1 interacts with TRMT1ProteinHetionet hetionet:interacts:55621-7013Inferred only
UBC interacts with TRMT1ProteinHetionet hetionet:interacts:55621-7316Inferred only
TRMT1 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
TRMT1 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
TRMT1 participates in tRNA modification in the nucleus and cytosolPathwayReactome R-HSA-6782315Inferred only
TRMT1 participates in tRNA processingPathwayReactome R-HSA-72306Inferred only
ABCG2 decreases the expression of TRMT1ProteinHetionet hetionet:regulates:9429-55621Inferred only
TRMT1 increases the expression of AGR2ProteinHetionet hetionet:regulates:55621-10551Inferred only
BNIP3 increases the expression of TRMT1ProteinHetionet hetionet:regulates:664-55621Inferred only

Show the remaining 12

CCNB2 increases the expression of TRMT1ProteinHetionet hetionet:regulates:9133-55621Inferred only
CD58 increases the expression of TRMT1ProteinHetionet hetionet:regulates:965-55621Inferred only
CDC25A increases the expression of TRMT1ProteinHetionet hetionet:regulates:993-55621Inferred only
TRMT1 increases the expression of HLA-DMAProteinHetionet hetionet:regulates:55621-3108Inferred only
IL1RAP increases the expression of TRMT1ProteinHetionet hetionet:regulates:3556-55621Inferred only
INPPL1 increases the expression of TRMT1ProteinHetionet hetionet:regulates:3636-55621Inferred only
NQO1 increases the expression of TRMT1ProteinHetionet hetionet:regulates:1728-55621Inferred only
RAB11A increases the expression of TRMT1ProteinHetionet hetionet:regulates:8766-55621Inferred only
TNIP1 increases the expression of TRMT1ProteinHetionet hetionet:regulates:10318-55621Inferred only
TXNRD1 increases the expression of TRMT1ProteinHetionet hetionet:regulates:7296-55621Inferred only
UBA52 increases the expression of TRMT1ProteinHetionet hetionet:regulates:7311-55621Inferred only
ZFX increases the expression of TRMT1ProteinHetionet hetionet:regulates:7543-55621Inferred only

Reactions

2 reactions

proton+CHEBI:16680+MAM03061cS-adenosyl-L-methionine+MAM03084c
Catalysed by TRMT11 or TRMT1
Reaction pageReversibleBalance undeterminableEC 2.1.1.214, 2.1.1.215, 2.1.1.216cytosol
Human-GEM MAR09519CC BY 4.0Reference data
CHEBI:74269+2S-adenosyl-L-methionineCHEBI:74513+2S-adenosyl-L-homocysteine+2hydron
Catalysed by

Other names

6 names

Resolves to: TRMT1

Also called: guanine(26)-N(2)hTRM1tRNA 2,2-dimethylguanosine-26 methyltransferasetRNA methyltransferase 1tRNA(guanine-26,N(2)-N(2)) methyltransferasetRNA(m(2,2)G26)dimethyltransferase

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