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Proteins/UNIPROT:Q9ULQ1
Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles. Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable)..
(Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm..
Function from UniProtKB (Q9ULQ1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
12 statements
12 statements · 5 reference databases · Subject: TPCN1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea
3 reactions
Transported by SCN1A or SCN2A or SCN3A or SCN4A or SCN5A or SCN7A or SCN8A or SCN9A or SCN10A or SCN11A or HCN1 or HCN4 and 5 more alternatives
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01527CC BY 4.0Reference data
4 names
Resolves to: TPCN1
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:34963CC BY 4.0Reference data