Proteins/UNIPROT:Q9P1W3

TMEM63C

ProteinUNIPROT:Q9P1W3

Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress. In contrast to TMEM63B, does not show phospholipid scramblase activity. Enriched in mitochondria-ER contact sites where it may regulate the metabolite flux and organelles' morphologies in response to osmotic changes. In particular may regulate mitochondrial motility and function in motor neuron axons. Required for the functional integrity of the kidney glomerular filtration barrier (By similarity)..

Function from UniProtKB (Q9P1W3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

spastic paraplegia 87, autosomal recessive has a germline basis in TMEM63CDiseaseGenCC HGNC:23787|MONDO:0031019Inferred only

Statements

11 statements

11 statements · 2 reference databases · Subject: TMEM63C · Sources: Hetionet, Rhea

Order

CCDC22 covaries with TMEM63CProteinHetionet hetionet:covaries:28952-57156Inferred only
TMEM63C covaries with ERI3ProteinHetionet hetionet:covaries:57156-79033Inferred only
TMEM63C covaries with FBH1ProteinHetionet hetionet:covaries:57156-84893Inferred only
HTR2C covaries with TMEM63CProteinHetionet hetionet:covaries:3358-57156Inferred only
MICOS13 covaries with TMEM63CProteinHetionet hetionet:covaries:125988-57156Inferred only
NICOL1 covaries with TMEM63CProteinHetionet hetionet:covaries:401115-57156Inferred only
OBSL1 covaries with TMEM63CProteinHetionet hetionet:covaries:23363-57156Inferred only
TFE3 covaries with TMEM63CProteinHetionet hetionet:covaries:57156-7030Inferred only
ZNF197 covaries with TMEM63CProteinHetionet hetionet:covaries:10168-57156Inferred only
TMEM63C covaries with ZNF26ProteinHetionet hetionet:covaries:57156-7574Inferred only
Ca(2+) is transported by TMEM63CCompoundRhea RHEA:29671Inferred only

Reactions

1 reaction

Ca(2+)Ca(2+)
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data

Other names

5 names

Resolves to: TMEM63C

Also called: C14orf171Calcium permeable stress-gated cation channel 1CSC1hTMEM63CTransmembrane protein 63C

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