Proteins/UNIPROT:O43790

KRT86

ProteinUNIPROT:O43790

Structural component of intermediate filaments in the hair shaft. Forms obligate heterodimers with type I hair keratins, which assemble into keratin intermediate filaments that contribute to the structural integrity and mechanical strength of the hair shaft..

Function from UniProtKB (O43790), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

monilethrix has a germline basis in KRT86DiseaseGenCC HGNC:6463|MONDO:0008009Inferred only
monilethrix-1 has a germline basis in KRT86DiseaseGenCC HGNC:6463|MONDO:0700343Inferred only

Statements

17 statements

17 statements · 2 reference databases · Subject: KRT86 · Sources: Hetionet, Reactome

Order

AP3D1 covaries with KRT86ProteinHetionet hetionet:covaries:3892-8943Inferred only
KRT86 covaries with AQP5ProteinHetionet hetionet:covaries:362-3892Inferred only
KRT86 covaries with FTH1ProteinHetionet hetionet:covaries:2495-3892Inferred only
KRT33B covaries with KRT86ProteinHetionet hetionet:covaries:3884-3892Inferred only
KRT37 covaries with KRT86ProteinHetionet hetionet:covaries:3892-8688Inferred only
KRT86 covaries with KRT81ProteinHetionet hetionet:covaries:3887-3892Inferred only
KRT83 covaries with KRT86ProteinHetionet hetionet:covaries:3889-3892Inferred only
KRTAP1-3 covaries with KRT86ProteinHetionet hetionet:covaries:3892-81850Inferred only
KRT86 covaries with MS4A2ProteinHetionet hetionet:covaries:2206-3892Inferred only
PLA2G10 covaries with KRT86ProteinHetionet hetionet:covaries:3892-8399Inferred only
KRT86 covaries with RSRP1ProteinHetionet hetionet:covaries:3892-57035Inferred only
SCN11A covaries with KRT86ProteinHetionet hetionet:covaries:11280-3892Inferred only

Show the remaining 5

SPTB covaries with KRT86ProteinHetionet hetionet:covaries:3892-6710Inferred only
KRT86 interacts with UBCProteinHetionet hetionet:interacts:3892-7316Inferred only
KRT86 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
KRT86 participates in Formation of the cornified envelopePathwayReactome R-HSA-6809371Inferred only
KRT86 participates in KeratinizationPathwayReactome R-HSA-6805567Inferred only

Other names

7 names

Resolves to: KRT86

Also called: Hair keratin K2.11hHb6K86Keratin-86KRTHB6Type II hair keratin Hb6Type-II keratin Kb26

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