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Proteins/UNIPROT:Q9H2V7
Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol. Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids. Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), can also transport lysophosphatidylglycerol (LPG), but not other anionic lysophospholipids, sphingosine, nor sphingomyelin. Transports lysophospholipids with saturated, monounsaturated, and polyunsaturated fatty acids, such as 1-hexadecanoyl-sn-glycero-3-phosphocholine, 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine, respectively. Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine. Lysosomal LPC could function as intracellular signaling messenger. Essential player in lysosomal homeostasis. Crucial for cell survival under conditions of nutrient limitation. May be involved in necrotic or autophagic cell death..
Function from UniProtKB (Q9H2V7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
47 statements
47 statements · 4 reference databases · Subject: SPNS1 · Sources: Hetionet, Human Protein Atlas, Rhea, WikiPathways
13 reactions
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+hydron1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+hydron
Transported by SPNS1
Reaction pageDirection not assertedBalanced
Rhea RHEA:74411CC BY 4.0Reference data
1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+hydron1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+hydron
Transported by SPNS1
Reaction pageDirection not assertedBalanced
3 names
Resolves to: SPNS1
1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)+hydron1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)+hydron
Transported by SPNS1
Reaction pageDirection not assertedBalanced
Rhea RHEA:74419CC BY 4.0Reference data
CHEBI:73873+hydronCHEBI:73873+hydron
Transported by SPNS1
Reaction pageDirection not assertedBalanced
Rhea RHEA:74423CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphocholine+hydron1-hexadecanoyl-sn-glycero-3-phosphocholine+hydron
Transported by SPNS1
Reaction pageDirection not assertedBalanced
Rhea RHEA:74427CC BY 4.0Reference data
1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine+hydron1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine+hydron
Transported by SPNS1
Reaction pageDirection not assertedBalanced
Rhea RHEA:74431CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphocholine+hydrona 1-acyl-sn-glycero-3-phosphocholine+hydron
Transported by SPNS1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:74435CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphoethanolamine+hydrona 1-acyl-sn-glycero-3-phosphoethanolamine+hydron
Transported by SPNS1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:74439CC BY 4.0Reference data
1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)+hydron1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)+hydron
Transported by SPNS1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:74443CC BY 4.0Reference data
a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine+hydrona 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine+hydron
Transported by SPNS1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:74447CC BY 4.0Reference data
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+hydron1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+hydron
Transported by SPNS1
Reaction pageDirection not assertedBalanced
Rhea RHEA:74451CC BY 4.0Reference data
a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine+hydrona 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine+hydron
Transported by SPNS1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:74455CC BY 4.0Reference data