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Proteins/UNIPROT:P57103
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination. Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity)..
Function from UniProtKB (P57103), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
26 statements
26 statements · 6 reference databases · Subject: SLC8A3 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
Ca(2+)+3sodium(1+)Ca(2+)+3sodium(1+)
Transported by SLC8A3 or SLC8A2 or SLC8A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07630CC BY 4.0Reference data
Ca(2+)+3sodium(1+)Ca(2+)+3sodium(1+)
Transported by SLC8A1
3 names
Resolves to: SLC8A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:69955CC BY 4.0Reference data