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Proteins/UNIPROT:Q6U841
Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH. Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange. Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity)..
Function from UniProtKB (Q6U841), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
37 statements
37 statements · 8 reference databases · Subject: SLC4A10 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
chlorine(.)+proton+hydrogencarbonate+sodium(1+)chlorine(.)+proton+hydrogencarbonate+sodium(1+)
Transported by SLC4A8 or SLC4A10
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR01525CC BY 4.0Reference data
4 names
Resolves to: SLC4A10
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06532CC BY 4.0Reference data
2hydrogencarbonate+chloride+sodium(1+)2hydrogencarbonate+chloride+sodium(1+)
Transported by SLC4A8 or SLC4A10 or SLC4A9
Reaction pageDirection not assertedBalanced
Rhea RHEA:72739CC BY 4.0Reference data