malignant migrating partial seizures of infancy
Findings
No curated finding names malignant migrating partial seizures of infancy yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A very rare severe form of epilepsy with poor prognosis that usually begins within a few weeks of birth. The seizure activity can appear in multiple locations in the brain or migrate from one region to another during an episode. It results in severe developmental delay.
Definition from the Mondo Disease Ontology (MONDO:0017385), read 2026-09-29. CC BY 4.0.
Features
25 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Cognitive impairmentHPOHP:0100543
- Very frequent (80% to 99% of cases)
- Developmental regressionHPOHP:0002376
- Very frequent (80% to 99% of cases)
- Functional motor deficitHPOHP:0004302
- Very frequent (80% to 99% of cases)
- Inability to walkHPOHP:0002540
- Very frequent (80% to 99% of cases)
- Multifocal epileptiform dischargesHPOHP:0010841
- Very frequent (80% to 99% of cases)
- Neurodevelopmental delayHPOHP:0012758
- Very frequent (80% to 99% of cases)
- Bilateral tonic-clonic seizureHPOHP:0002069
- Frequent (30% to 79% of cases)
- Bilateral tonic-clonic seizure with focal onsetHPOHP:0007334
- Frequent (30% to 79% of cases)
- Cerebral atrophyHPOHP:0002059
- Frequent (30% to 79% of cases)
- Focal emotional seizure with laughingHPOHP:0010821
- Frequent (30% to 79% of cases)
- Focal hemiclonic seizureHPOHP:0006813
- Frequent (30% to 79% of cases)
- Focal impaired awareness seizureHPOHP:0002384
- Frequent (30% to 79% of cases)
Show the remaining 13
- HypotoniaHPOHP:0001252
- Frequent (30% to 79% of cases)
- MicrocephalyHPOHP:0000252
- Frequent (30% to 79% of cases)
- Myoclonic seizureHPOHP:0032794
- Frequent (30% to 79% of cases)
- Abnormal corpus callosum morphologyHPOHP:0001273
- Occasional (5% to 29% of cases)
- Aortopulmonary collateral arteriesHPOHP:0031834
- Occasional (5% to 29% of cases)
- Delayed myelinationHPOHP:0012448
- Occasional (5% to 29% of cases)
Genes
9 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- KCNT1HGNC:18865
- Definitive · G2P · Autosomal dominant · 2015
- Supportive · Orphanet · Autosomal dominant · 2021
- SLC12A5HGNC:13818
- Strong · G2P · Autosomal recessive · 2021
- Supportive · Orphanet · Autosomal dominant · 2021
- KCNQ2HGNC:6296
- Supportive · Orphanet · Autosomal dominant · 2021
- PIGAHGNC:8957
- Supportive · Orphanet · Autosomal dominant · 2021
- PLCB1HGNC:15917
- · Orphanet · Autosomal dominant · 2021
Where it sits
Other names
10 names
Resolves to: malignant migrating partial seizures of infancy
- Also called
- EIMFSepilepsy of infancy with migrating focal seizuresmalignant migrating partial epilepsy of infancymalignant migrating Partial seizures in infancymigrating partial epilepsy of infancymigrating Partial seizures in infancymigrating partial seizures of infancyMMPEIMMPSIMPEI