Proteins/UNIPROT:Q149N8

SHPRH

ProteinUNIPROT:Q149N8

E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'..

Function from UniProtKB (Q149N8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 2 reference databases · Subject: SHPRH · Sources: Hetionet, Reactome

Order

ARHGAP40 covaries with SHPRHProteinHetionet hetionet:covaries:257218-343578Inferred only
SHPRH covaries with PIAS4ProteinHetionet hetionet:covaries:257218-51588Inferred only
SHPRH covaries with SYNGR3ProteinHetionet hetionet:covaries:257218-9143Inferred only
SHPRH covaries with WFDC1ProteinHetionet hetionet:covaries:257218-58189Inferred only
FBXW7 interacts with SHPRHProteinHetionet hetionet:interacts:257218-55294Inferred only
FDFT1 interacts with SHPRHProteinHetionet hetionet:interacts:2222-257218Inferred only
HLTF interacts with SHPRHProteinHetionet hetionet:interacts:257218-6596Inferred only
LPP interacts with SHPRHProteinHetionet hetionet:interacts:257218-4026Inferred only
PCNA interacts with SHPRHProteinHetionet hetionet:interacts:257218-5111Inferred only
RAD18 interacts with SHPRHProteinHetionet hetionet:interacts:257218-56852Inferred only
UBC interacts with SHPRHProteinHetionet hetionet:interacts:257218-7316Inferred only
UBE2N interacts with SHPRHProteinHetionet hetionet:interacts:257218-7334Inferred only

Show the remaining 5

UBE2V2 interacts with SHPRHProteinHetionet hetionet:interacts:257218-7336Inferred only
SHPRH participates in E3 ubiquitin ligases ubiquitinate target proteinsPathwayReactome R-HSA-8866654Inferred only
SHPRH participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
SHPRH participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
SHPRH participates in Protein ubiquitinationPathwayReactome R-HSA-8852135Inferred only

Reactions

1 reaction

MAM00204c+ATP+MAM03105cMAM00214c+AMP+diphosphate(3-)
Catalysed by RNF40 & RNF20 or SAE1 & UBA2 or RING1 & RNF2 or HECW1 or MYCBP2 or MYLIP or UBE3C or RNF216 or UBR7 or RNF14 or UBR2

Other names

3 names

Resolves to: SHPRH

Also called: KIAA2023RING-type E3 ubiquitin transferase SHPRHSNF2, histone-linker, PHD and RING finger domain-containing helicase

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