Proteins/UNIPROT:Q99500

S1PR3

ProteinUNIPROT:Q99500

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis..

Function from UniProtKB (Q99500), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

35 statements

35 statements · 4 reference databases · Subject: S1PR3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

S1PR3 interacts with GNA13ProteinHetionet hetionet:interacts:10672-1903Inferred only
S1PR3 interacts with GNAQProteinHetionet hetionet:interacts:1903-2776Inferred only
S1PR3 interacts with HTR1AProteinHetionet hetionet:interacts:1903-3350Inferred only
S1PR3 interacts with UBCProteinHetionet hetionet:interacts:1903-7316Inferred only
S1PR3 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
S1PR3 participates in ESR-mediated signalingPathwayReactome R-HSA-8939211Inferred only
S1PR3 participates in Extra-nuclear estrogen signalingPathwayReactome R-HSA-9009391Inferred only
S1PR3 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
S1PR3 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
S1PR3 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
S1PR3 participates in Lysosphingolipid and LPA receptorsPathwayReactome R-HSA-419408Inferred only
S1PR3 participates in Modulation of PI3K Akt mTOR signaling by bioactive sphingolipidsPathwayWikiPathways WP5192Inferred only

Show the remaining 23

S1PR3 participates in Multiple sclerosis mechanism and therapiesPathwayWikiPathways WP5540Inferred only
S1PR3 participates in S1P receptor signal transductionPathwayWikiPathways WP26Inferred only
S1PR3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
S1PR3 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
S1PR3 participates in Signaling by Nuclear ReceptorsPathwayReactome R-HSA-9006931Inferred only
S1PR3 participates in Small ligand GPCRsPathwayWikiPathways WP247Inferred only
S1PR3 regulates negative regulation of establishment of endothelial barrierBiological processgene ontology Q99500|GO:1903141Inferred only
S1PR3 regulates positive regulation of cell population proliferationBiological processgene ontology Q99500|GO:0008284Inferred only
S1PR3 regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology Q99500|GO:0007204Inferred only
S1PR3 decreases the expression of B4GAT1ProteinHetionet hetionet:regulates:1903-11041Inferred only
S1PR3 decreases the expression of DNAJA3ProteinHetionet hetionet:regulates:1903-9093Inferred only
S1PR3 decreases the expression of ECH1ProteinHetionet hetionet:regulates:1903-1891Inferred only
S1PR3 decreases the expression of INSIG1ProteinHetionet hetionet:regulates:1903-3638Inferred only
S1PR3 decreases the expression of LAP3ProteinHetionet hetionet:regulates:1903-51056Inferred only
S1PR3 decreases the expression of LIPAProteinHetionet hetionet:regulates:1903-3988Inferred only
S1PR3 decreases the expression of MTERF3ProteinHetionet hetionet:regulates:1903-51001Inferred only
S1PR3 increases the expression of NPC1ProteinHetionet hetionet:regulates:1903-4864Inferred only
S1PR3 decreases the expression of PCNAProteinHetionet hetionet:regulates:1903-5111Inferred only
S1PR3 decreases the expression of POLR2IProteinHetionet hetionet:regulates:1903-5438Inferred only
S1PR3 increases the expression of RELBProteinHetionet hetionet:regulates:1903-5971Inferred only
S1PR3 decreases the expression of RTN2ProteinHetionet hetionet:regulates:1903-6253Inferred only
S1PR3 decreases the expression of SLC38A1ProteinHetionet hetionet:regulates:1903-81539Inferred only
S1PR3 decreases the expression of UBE3CProteinHetionet hetionet:regulates:1903-9690Inferred only

Other names

8 names

Resolves to: S1PR3

Also called: C9orf108C9orf47EDG3Endothelial differentiation G protein-coupled receptor 3S1P receptor 3S1P receptor Edg-3S1P3Sphingosine 1-phosphate receptor Edg-3

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