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Proteins/UNIPROT:Q92730

RND1

Protein·UNIPROT:Q92730

Open in the graph

Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments..

Function from UniProtKB (Q92730), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

31 statements

31 statements · 5 reference databases · Subject: RND1 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways

Search this listOrder

ARHGAP4 covaries with RND1ProteinHetionet hetionet:covaries:27289-393Inferred only
ELOC covaries with RND1ProteinHetionet hetionet:covaries:27289-6921Inferred only
EPOP covaries with RND1ProteinHetionet hetionet:covaries:100170841-27289Inferred only
IL17REL covaries with RND1ProteinHetionet hetionet:covaries:27289-400935Inferred only
RND1 interacts with CREB3L2ProteinHetionet hetionet:interacts:27289-64764Inferred only
GRB7 interacts with RND1ProteinHetionet hetionet:interacts:27289-2886Inferred only
ID3 interacts with RND1ProteinHetionet hetionet:interacts:27289-3399Inferred only
PDE6D interacts with RND1ProteinHetionet hetionet:interacts:27289-5147Inferred only
PLXNA1 interacts with RND1ProteinHetionet hetionet:interacts:27289-5361Inferred only
PLXNB1 interacts with RND1ProteinHetionet hetionet:interacts:27289-5364Inferred only
PLXNB2 interacts with RND1ProteinHetionet hetionet:interacts:23654-27289Inferred only
RND1 interacts with UBXN11ProteinHetionet hetionet:interacts:27289-91544Inferred only

Show the remaining 19

ZNF212 interacts with RND1ProteinHetionet hetionet:interacts:27289-7988Inferred only
RND1 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
RND1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
RND1 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
RND1 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
RND1 participates in RND1 GTPase cyclePathwayReactome R-HSA-9696273Inferred only
RND1 participates in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionPathwayReactome R-HSA-399955Inferred only
RND1 participates in Sema4D in semaphorin signalingPathwayReactome R-HSA-400685Inferred only
RND1 participates in Sema4D induced cell migration and growth-cone collapsePathwayReactome R-HSA-416572Inferred only
RND1 participates in Sema4D mediated inhibition of cell attachment and migrationPathwayReactome R-HSA-416550Inferred only
RND1 participates in Semaphorin interactionsPathwayReactome R-HSA-373755Inferred only
RND1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
RND1 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
RND1 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
RND1 participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only
RND1 regulates negative regulation of cell adhesionBiological processgene ontology Q92730|GO:0007162Inferred only
RND1 regulates regulation of actin cytoskeleton organizationBiological processgene ontology Q92730|GO:0032956Inferred only
BCKDHA increases the expression of RND1ProteinHetionet hetionet:regulates:593-27289Inferred only
RND1 requires the cofactor magnesium(2+)CompoundUniProt Q92730Inferred only

Reactions

1 reaction

GTP+waterGDP+hydrogenphosphate+hydron
Catalysed by IRGM or RAB19 or TUBAL3 or GTPBP1 or RAB27B or RHOD or DNM1L or MRAS or RAB29 or OPA1 or EIF5B or ENTPD3 and 183 more alternatives
Reaction page

Other names

2 names

Resolves to: RND1

Also called: Rho family GTPase 1RHO6

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Balanced

Rhea RHEA:19669CC BY 4.0Reference data