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Proteins/UNIPROT:Q96E14

RMI2

Protein·UNIPROT:Q96E14

Open in the graph

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM..

Function from UniProtKB (Q96E14), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

Bloom syndrome has a germline basis in RMI2DiseaseGenCC HGNC:28349|MONDO:0008876Inferred only

Statements

38 statements

38 statements · 4 reference databases · Subject: RMI2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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BLM interacts with RMI2ProteinHetionet hetionet:interacts:116028-641Inferred only
RMI1 interacts with RMI2ProteinHetionet hetionet:interacts:116028-80010Inferred only
TOP3A interacts with RMI2ProteinHetionet hetionet:interacts:116028-7156Inferred only
UBC interacts with RMI2ProteinHetionet hetionet:interacts:116028-7316Inferred only
RMI2 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
RMI2 participates in Cell Cycle CheckpointsPathwayReactome R-HSA-69620Inferred only
RMI2 participates in Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding functionPathwayReactome R-HSA-9704331Inferred only
RMI2 participates in Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding functionPathwayReactome R-HSA-9704646Inferred only
RMI2 participates in Defective homologous recombination repair (HRR) due to BRCA1 loss of functionPathwayReactome R-HSA-9701192Inferred only
RMI2 participates in Defective homologous recombination repair (HRR) due to BRCA2 loss of functionPathwayReactome R-HSA-9701190Inferred only
RMI2 participates in Defective homologous recombination repair (HRR) due to PALB2 loss of functionPathwayReactome R-HSA-9701193Inferred only
RMI2 participates in DiseasePathwayReactome R-HSA-1643685Inferred only

Show the remaining 26

RMI2 participates in Diseases of DNA Double-Strand Break RepairPathwayReactome R-HSA-9675136Inferred only
RMI2 participates in Diseases of DNA repairPathwayReactome R-HSA-9675135Inferred only
RMI2 participates in DNA Double-Strand Break RepairPathwayReactome R-HSA-5693532Inferred only
RMI2 participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
RMI2 participates in G2/M CheckpointsPathwayReactome R-HSA-69481Inferred only
RMI2 participates in G2/M DNA damage checkpointPathwayReactome R-HSA-69473Inferred only
RMI2 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
RMI2 participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
RMI2 participates in HDR through Homologous Recombination (HRR)PathwayReactome R-HSA-5685942Inferred only
RMI2 participates in HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)PathwayReactome R-HSA-5693567Inferred only
RMI2 participates in HDR through Single Strand Annealing (SSA)PathwayReactome R-HSA-5685938Inferred only
RMI2 participates in Homologous DNA Pairing and Strand ExchangePathwayReactome R-HSA-5693579Inferred only
RMI2 participates in Homology Directed RepairPathwayReactome R-HSA-5693538Inferred only
RMI2 participates in Impaired BRCA2 binding to PALB2PathwayReactome R-HSA-9709603Inferred only
RMI2 participates in Impaired BRCA2 binding to RAD51PathwayReactome R-HSA-9709570Inferred only
RMI2 participates in Presynaptic phase of homologous DNA pairing and strand exchangePathwayReactome R-HSA-5693616Inferred only
RMI2 participates in Processing of DNA double-strand break endsPathwayReactome R-HSA-5693607Inferred only
RMI2 participates in Regulation of TP53 ActivityPathwayReactome R-HSA-5633007Inferred only
RMI2 participates in Regulation of TP53 Activity through PhosphorylationPathwayReactome R-HSA-6804756Inferred only
RMI2 participates in Resolution of D-Loop StructuresPathwayReactome R-HSA-5693537Inferred only
RMI2 participates in Resolution of D-loop Structures through Holliday Junction IntermediatesPathwayReactome R-HSA-5693568Inferred only
RMI2 participates in Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)PathwayReactome R-HSA-5693554Inferred only
RMI2 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
RMI2 participates in Smith Magenis and Potocki Lupski syndrome copy number variationPathwayWikiPathways WP5381Inferred only
RMI2 participates in Transcriptional Regulation by TP53PathwayReactome R-HSA-3700989Inferred only
RMI2 regulates regulation of sister chromatid segregationBiological processgene ontology Q96E14|GO:0033045Inferred only

Other names

4 names

Resolves to: RMI2

Also called: BLAP18BLM-associated protein of 18 kDaC16orf75hRMI2

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