Pathway
Impaired BRCA2 binding to PALB2
This pathway describes BRCA2 missense mutations that affect the N-terminus of BRCA2 and impair the ability of BRCA2 to bind PALB2, which is a crucial step in homologous recombination repair (HRR) of DNA double-strand breaks (DSBs).
REACT:R-HSA-9709603Reactome
What the reference databases state
Statements
24 statements
24 statements · 1 reference database · Subject: Impaired BRCA2 binding to PALB2 · Sources: Reactome
- ATM participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- BARD1 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- BLM participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- BRCA1 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- BRCA2 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- BRIP1 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- DNA2 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- EXO1 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- KAT5 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- MRE11 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- NBN participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- PALB2 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
Show the remaining 12
- RAD50 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- RAD51 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- RAD51AP1 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- RAD51B participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- RAD51C participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- RAD51D participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- RBBP8 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- RMI1 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- RMI2 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- TOP3A participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- WRN participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only
- XRCC2 participates in Impaired BRCA2 binding to PALB2ProteinReactome R-HSA-9709603Inferred only