Proteins/UNIPROT:Q00577

PURA

ProteinUNIPROT:Q00577

This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination..

Function from UniProtKB (Q00577), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

complex neurodevelopmental disorder has a germline basis in PURADiseaseGenCC HGNC:9701|MONDO:0100038Inferred only
PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome due to a point mutation has a germline basis in PURADiseaseGenCC HGNC:9701|MONDO:0014512Inferred only

Statements

33 statements

33 statements · 3 reference databases · Subject: PURA · Sources: gene ontology, Hetionet, WikiPathways

Order

PURA interacts with ADAP1ProteinHetionet hetionet:interacts:11033-5813Inferred only
PURA interacts with CAND1ProteinHetionet hetionet:interacts:55832-5813Inferred only
CCNT1 interacts with PURAProteinHetionet hetionet:interacts:5813-904Inferred only
CDK5 interacts with PURAProteinHetionet hetionet:interacts:1020-5813Inferred only
PURA interacts with CUL1ProteinHetionet hetionet:interacts:5813-8454Inferred only
PURA interacts with CUL3ProteinHetionet hetionet:interacts:5813-8452Inferred only
E2F1 interacts with PURAProteinHetionet hetionet:interacts:1869-5813Inferred only
PURA interacts with MEPCEProteinHetionet hetionet:interacts:56257-5813Inferred only
PURA interacts with PCLAFProteinHetionet hetionet:interacts:5813-9768Inferred only
PURA interacts with PURBProteinHetionet hetionet:interacts:5813-5814Inferred only
PURA interacts with RB1ProteinHetionet hetionet:interacts:5813-5925Inferred only
PURA interacts with SP1ProteinHetionet hetionet:interacts:5813-6667Inferred only

Show the remaining 21

PURA interacts with UBCProteinHetionet hetionet:interacts:5813-7316Inferred only
YBX1 interacts with PURAProteinHetionet hetionet:interacts:4904-5813Inferred only
PURA participates in Exercise induced circadian regulationPathwayWikiPathways WP410Inferred only
PURA participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
PURA regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q00577|GO:0000122Inferred only
PURA regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q00577|GO:0006357Inferred only
B4GALT3 increases the expression of PURAProteinHetionet hetionet:regulates:8703-5813Inferred only
PURA decreases the expression of BADProteinHetionet hetionet:regulates:5813-572Inferred only
PURA decreases the expression of CSRP1ProteinHetionet hetionet:regulates:5813-1465Inferred only
PURA decreases the expression of DNAJA3ProteinHetionet hetionet:regulates:5813-9093Inferred only
PURA decreases the expression of DPH2ProteinHetionet hetionet:regulates:5813-1802Inferred only
PURA decreases the expression of GDF15ProteinHetionet hetionet:regulates:5813-9518Inferred only
HADH decreases the expression of PURAProteinHetionet hetionet:regulates:3033-5813Inferred only
PURA increases the expression of MAP7ProteinHetionet hetionet:regulates:5813-9053Inferred only
PURA decreases the expression of PLEKHM1ProteinHetionet hetionet:regulates:5813-9842Inferred only
PURA decreases the expression of PRUNE2ProteinHetionet hetionet:regulates:5813-158471Inferred only
PURA decreases the expression of PTPN1ProteinHetionet hetionet:regulates:5813-5770Inferred only
PURA decreases the expression of RPIAProteinHetionet hetionet:regulates:5813-22934Inferred only
PURA decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:5813-6192Inferred only
PURA increases the expression of SLC1A4ProteinHetionet hetionet:regulates:5813-6509Inferred only
PURA decreases the expression of WASHC5ProteinHetionet hetionet:regulates:5813-9897Inferred only

Other names

3 names

Resolves to: PURA

Also called: PUR1Purine-rich single-stranded DNA-binding protein alphaTranscriptional activator protein Pur-alpha

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