Proteins/UNIPROT:Q9H3S7

PTPN23

ProteinUNIPROT:Q9H3S7

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis..

Function from UniProtKB (Q9H3S7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

neurodevelopmental disorder and structural brain anomalies with or without seizures and spasticity has a germline basis in PTPN23DiseaseGenCC HGNC:14406|MONDO:0030046Inferred only

Statements

31 statements

31 statements · 3 reference databases · Subject: PTPN23 · Sources: gene ontology, Hetionet, Reactome

Order

PTPN23 covaries with ACTL9ProteinHetionet hetionet:covaries:25930-284382Inferred only
CDKL2 covaries with PTPN23ProteinHetionet hetionet:covaries:25930-8999Inferred only
CSPG5 covaries with PTPN23ProteinHetionet hetionet:covaries:10675-25930Inferred only
KRTAP20-2 covaries with PTPN23ProteinHetionet hetionet:covaries:25930-337976Inferred only
PKHD1L1 covaries with PTPN23ProteinHetionet hetionet:covaries:25930-93035Inferred only
PTPN23 covaries with PLCD3ProteinHetionet hetionet:covaries:113026-25930Inferred only
PTPN23 covaries with SIRPB2ProteinHetionet hetionet:covaries:25930-284759Inferred only
PTPN23 covaries with THBDProteinHetionet hetionet:covaries:25930-7056Inferred only
PTPN23 interacts with ALG2ProteinHetionet hetionet:interacts:25930-85365Inferred only
PTPN23 interacts with CHMP4BProteinHetionet hetionet:interacts:128866-25930Inferred only
PTPN23 interacts with DDX24ProteinHetionet hetionet:interacts:25930-57062Inferred only
GRAP2 interacts with PTPN23ProteinHetionet hetionet:interacts:25930-9402Inferred only

Show the remaining 19

GRB2 interacts with PTPN23ProteinHetionet hetionet:interacts:25930-2885Inferred only
ITGA4 interacts with PTPN23ProteinHetionet hetionet:interacts:25930-3676Inferred only
PTPN23 interacts with LRRK2ProteinHetionet hetionet:interacts:120892-25930Inferred only
PTPN23 interacts with PPP4R3BProteinHetionet hetionet:interacts:25930-57223Inferred only
SH3GL2 interacts with PTPN23ProteinHetionet hetionet:interacts:25930-6456Inferred only
STAM2 interacts with PTPN23ProteinHetionet hetionet:interacts:10254-25930Inferred only
TSG101 interacts with PTPN23ProteinHetionet hetionet:interacts:25930-7251Inferred only
UBC interacts with PTPN23ProteinHetionet hetionet:interacts:25930-7316Inferred only
VCP interacts with PTPN23ProteinHetionet hetionet:interacts:25930-7415Inferred only
PTPN23 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
PTPN23 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
PTPN23 participates in Interleukin-1 family signalingPathwayReactome R-HSA-446652Inferred only
PTPN23 participates in Interleukin-37 signalingPathwayReactome R-HSA-9008059Inferred only
PTPN23 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
PTPN23 regulates negative regulation of epithelial cell migrationBiological processgene ontology Q9H3S7|GO:0010633Inferred only
PTPN23 regulates positive regulation of adherens junction organizationBiological processgene ontology Q9H3S7|GO:1903393Inferred only
PTPN23 regulates positive regulation of early endosome to late endosome transportBiological processgene ontology Q9H3S7|GO:2000643Inferred only
PTPN23 regulates positive regulation of homophilic cell adhesionBiological processgene ontology Q9H3S7|GO:1903387Inferred only
PTPN23 regulates positive regulation of Wnt protein secretionBiological processgene ontology Q9H3S7|GO:0061357Inferred only

Reactions

1 reaction

O-phospho-L-tyrosyl-[protein]+waterL-tyrosyl-[protein]+hydrogenphosphate
Catalysed by PGP or EYA2 or PTPRT or CDC14B or PTP4A3 or DUSP14 or EPM2A or EYA4 or PTPRC or PTPRF or ACP3 or PTPN2 and 71 more alternatives
Reaction pageLeft to rightBalance undeterminable

Other names

6 names

Resolves to: PTPN23

Also called: HD-PTPHis domain-containing protein tyrosine phosphataseKIAA1471Protein tyrosine phosphatase TD14PTP-TD14tyrosine phosphatase TD14

← Every protein Find it in the graph →