Proteins/UNIPROT:Q15678

PTPN14

ProteinUNIPROT:Q15678

Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor..

Function from UniProtKB (Q15678), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

lymphedema-posterior choanal atresia syndrome has a germline basis in PTPN14DiseaseGenCC HGNC:9647|MONDO:0013324Inferred only

Statements

20 statements

20 statements · 4 reference databases · Subject: PTPN14 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

DCAF16 covaries with PTPN14ProteinHetionet hetionet:covaries:54876-5784Inferred only
PVR covaries with PTPN14ProteinHetionet hetionet:covaries:5784-5817Inferred only
ZNF699 covaries with PTPN14ProteinHetionet hetionet:covaries:374879-5784Inferred only
CDH1 interacts with PTPN14ProteinHetionet hetionet:interacts:5784-999Inferred only
CTNNA2 interacts with PTPN14ProteinHetionet hetionet:interacts:1496-5784Inferred only
CTNNB1 interacts with PTPN14ProteinHetionet hetionet:interacts:1499-5784Inferred only
JUP interacts with PTPN14ProteinHetionet hetionet:interacts:3728-5784Inferred only
MYC interacts with PTPN14ProteinHetionet hetionet:interacts:4609-5784Inferred only
PTPN14 interacts with TJP1ProteinHetionet hetionet:interacts:5784-7082Inferred only
PTPN14 interacts with UBCProteinHetionet hetionet:interacts:5784-7316Inferred only
PTPN14 interacts with YAP1ProteinHetionet hetionet:interacts:10413-5784Inferred only
PTPN14 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only

Show the remaining 8

PTPN14 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
PTPN14 participates in Interleukin-1 family signalingPathwayReactome R-HSA-446652Inferred only
PTPN14 participates in Interleukin-37 signalingPathwayReactome R-HSA-9008059Inferred only
PTPN14 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
PTPN14 participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only
PTPN14 regulates negative regulation of cell population proliferationBiological processgene ontology Q15678|GO:0008285Inferred only
PTPN14 regulates positive regulation of hippo signalingBiological processgene ontology Q15678|GO:0035332Inferred only
PTPN14 regulates regulation of protein export from nucleusBiological processgene ontology Q15678|GO:0046825Inferred only

Reactions

1 reaction

O-phospho-L-tyrosyl-[protein]+waterL-tyrosyl-[protein]+hydrogenphosphate
Catalysed by PGP or EYA2 or PTPRT or CDC14B or PTP4A3 or DUSP14 or EPM2A or EYA4 or PTPRC or PTPRF or ACP3 or PTPN2 and 71 more alternatives
Reaction pageLeft to rightBalance undeterminable

Other names

3 names

Resolves to: PTPN14

Also called: PEZProtein-tyrosine phosphatase pezPTPD2

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