VAMP4

SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE). VAMP4 is a v-SNARE that functions in vesicle fusion with the plasma membrane. In skeletal muscle satellite cells, VAMP4 cooperates with its cognate SNAREs STX11 and SNAP23 to facilitate CD36 vesicular transport from endosomes to the plasma membrane, an essential step in muscle regeneration (By similarity)..

Function from UniProtKB (O75379), read 2026-09-23. CC BY 4.0.