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Proteins/UNIPROT:Q9UKX7
Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity)..
Function from UniProtKB (Q9UKX7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
92 statements
92 statements · 4 reference databases · Subject: NUP50 · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
2 reactions
4 names
Resolves to: NUP50
Reaction pageReversibleBalancedcytosol, nucleus
Human-GEM MAR07796CC BY 4.0Reference data
MAM02847nMAM02847c
Transported by NUP42 & NUP155 & TPR & NUP214 & NUP62 & NUP153 & RANBP2 & NUP98 & SEC13 & NUP107 & RAE1 & NUP160 & GLE1 & NUP188 & NUP54 & NUP93 & NUP43 & NUP37 & NUP35 & NUP210 & NUP133 & AHCTF1 & NUP205 & SEH1L & POM121 & NUP88 & NDC1 & NUP58 & NUP85 & NUP50 & DDX19B
Reaction pageLeft to rightBalance undeterminablenucleus, cytosol
Human-GEM MAR13086CC BY 4.0Reference data