Proteins/UNIPROT:P52948

NUP98

ProteinUNIPROT:P52948

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body)..

(Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro)..

Function from UniProtKB (P52948), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

18 statements

18 statements · 4 reference databases · Subject: NUP98 · Sources: gene ontology, Hetionet, Human-GEM, WikiPathways

Order

MAFF covaries with NUP98ProteinHetionet hetionet:covaries:23764-4928Inferred only
CSNK2A1 interacts with NUP98ProteinHetionet hetionet:interacts:1457-4928Inferred only
EP300 interacts with NUP98ProteinHetionet hetionet:interacts:2033-4928Inferred only
IPO5 interacts with NUP98ProteinHetionet hetionet:interacts:3843-4928Inferred only
NUP98 interacts with NUP133ProteinHetionet hetionet:interacts:4928-55746Inferred only
NUP98 interacts with NUP62ProteinHetionet hetionet:interacts:23636-4928Inferred only
NUP88 interacts with NUP98ProteinHetionet hetionet:interacts:4927-4928Inferred only
NUP98 interacts with NXF1ProteinHetionet hetionet:interacts:10482-4928Inferred only
NUP98 interacts with RAE1ProteinHetionet hetionet:interacts:4928-8480Inferred only
RCC1 interacts with NUP98ProteinHetionet hetionet:interacts:1104-4928Inferred only
TNPO1 interacts with NUP98ProteinHetionet hetionet:interacts:3842-4928Inferred only
NUP98 interacts with TPRProteinHetionet hetionet:interacts:4928-7175Inferred only

Show the remaining 6

NUP98 participates in Prader Willi and Angelman syndromePathwayWikiPathways WP3998Inferred only
NUP98 participates in SARS CoV 2 innate immunity evasion and cell specific immune responsePathwayWikiPathways WP5039Inferred only
NUP98 regulates positive regulation of mRNA splicing, via spliceosomeBiological processgene ontology P52948|GO:0048026Inferred only
ARFIP2 decreases the expression of NUP98ProteinHetionet hetionet:regulates:23647-4928Inferred only
BID decreases the expression of NUP98ProteinHetionet hetionet:regulates:637-4928Inferred only
UTP is transported by NUP98CompoundHuman-GEM MAR07796Inferred only

Reactions

2 reactions

UTPUTP
Transported by NUP98 & NUP107 & NUP160 & NUP43 & NUP37 & NUP133 & NUP85 or NUP50 or NUP188 or NUP93 or NUP88 or NUP155 or NUP153 or NUP214 or NUP210 or NUP42 or NUP54 or NUP58

Other names

7 names

Resolves to: NUP98

Also called: ]96 kDa nucleoporin98 kDa nucleoporinADAR2Nucleoporin Nup96Nucleoporin Nup98Nup96

← Every protein Find it in the graph →