Proteins/UNIPROT:Q96G61

NUDT11

ProteinUNIPROT:Q96G61Diphosphoinositol polyphosphate phosphohydrolase 3-beta

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate..

Function from UniProtKB (Q96G61), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

11 statements

11 statements · 4 reference databases · Subject: NUDT11 · Sources: Hetionet, Reactome, Rhea, UniProt

Order

NUDT11 covaries with CNTN6ProteinHetionet hetionet:covaries:27255-55190Inferred only
TRAF6 interacts with NUDT11ProteinHetionet hetionet:interacts:55190-7189Inferred only
UBC interacts with NUDT11ProteinHetionet hetionet:interacts:55190-7316Inferred only
NUDT11 participates in Inositol phosphate metabolismPathwayReactome R-HSA-1483249Inferred only
NUDT11 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
NUDT11 participates in Synthesis of pyrophosphates in the cytosolPathwayReactome R-HSA-1855167Inferred only
NUDT11 requires the cofactor magnesium(2+)CompoundUniProt Q96G61Inferred only
NUDT11 requires the cofactor Mn(2+)CompoundUniProt Q96G61Inferred only
adenosine 5'-pentaphosphate is a substrate of NUDT11CompoundRhea RHEA:32047Inferred only
P(1),P(5)-bis(5'-adenosyl) pentaphosphate is a substrate of NUDT11CompoundRhea RHEA:32051Inferred only
P(1),P(6)-bis(5'-adenosyl) hexaphosphate is a substrate of NUDT11CompoundRhea RHEA:32047Inferred only

Reactions

4 reactions

MAM01133c+waterproton+MAM02492c+phosphate(3-)
Catalysed by NUDT10 or NUDT4 or NUDT11 or NUDT3
Reaction pageLeft to rightBalancedEC 3.6.1.52cytosol
Human-GEM MAR07655CC BY 4.0Reference data
MAM01710c+waterproton+MAM02493c+phosphate(3-)
Catalysed by

Other names

10 names

Resolves to: NUDT11

Also called: APS1Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-betaDiadenosine hexaphosphate hydrolase (AMP-forming)DIPP-3-betaDIPP3-betaDIPP3BhAps1hDIPP3betaNucleoside diphosphate-linked moiety X motif 11Nudix motif 11

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