Proteins/UNIPROT:Q32MK0

MYLK3

ProteinUNIPROT:Q32MK0

Kinase that phosphorylates MYL2 in vitro (By similarity). Has been proposed to be calmodulin-dependent, although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin (By similarity). Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity)..

Function from UniProtKB (Q32MK0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

dilated cardiomyopathy has a germline basis in MYLK3DiseaseGenCC HGNC:29826|MONDO:0005021Inferred only

Statements

15 statements

15 statements · 4 reference databases · Subject: MYLK3 · Sources: gene ontology, Hetionet, UniProt, WikiPathways

Order

HSP90AA1 interacts with MYLK3ProteinHetionet hetionet:interacts:3320-91807Inferred only
HSP90AB1 interacts with MYLK3ProteinHetionet hetionet:interacts:3326-91807Inferred only
UBC interacts with MYLK3ProteinHetionet hetionet:interacts:7316-91807Inferred only
MYLK3 participates in Cardiac progenitor differentiationPathwayWikiPathways WP2406Inferred only
MYLK3 participates in Focal adhesionPathwayWikiPathways WP306Inferred only
MYLK3 participates in MicroRNAs in cardiomyocyte hypertrophyPathwayWikiPathways WP1544Inferred only
MYLK3 regulates positive regulation of membrane permeabilityBiological processgene ontology Q32MK0|GO:1905710Inferred only
MYLK3 regulates positive regulation of sarcomere organizationBiological processgene ontology Q32MK0|GO:0060298Inferred only
MYLK3 regulates positive regulation of tight junction disassemblyBiological processgene ontology Q32MK0|GO:1905075Inferred only
MYLK3 decreases the expression of IKZF1ProteinHetionet hetionet:regulates:91807-10320Inferred only
MYLK3 decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:91807-6192Inferred only
MYLK3 increases the expression of S100A7ProteinHetionet hetionet:regulates:91807-6278Inferred only

Show the remaining 3

MYLK3 decreases the expression of SLC35B1ProteinHetionet hetionet:regulates:91807-10237Inferred only
MYLK3 decreases the expression of TMSB15AProteinHetionet hetionet:regulates:91807-11013Inferred only
MYLK3 requires the cofactor magnesium(2+)CompoundUniProt Q32MK0Inferred only

Reactions

3 reactions

MAM00190c+ATPMAM00191c+ADP
Catalysed by MYLK or MYLK2 or MYLK3 or MYLK4
Reaction pageLeft to rightBalance undeterminableEC 2.7.11.18cytosol
Human-GEM MAR09493CC BY 4.0Reference data
L-seryl-[myosin light chain]+ATP(4-)O-phospho-L-seryl-[myosin light chain]+ADP(3-)+hydron
Catalysed by MYLK

Other names

3 names

Resolves to: MYLK3

Also called: Cardiac-MLCKCardiac-MyBP-C-associated Ca/CaM kinaseMLCK

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