Proteins/UNIPROT:Q9H1R3

MYLK2

ProteinUNIPROT:Q9H1R3

Ca(2+)/calmodulin-dependent kinase that phosphorylates the regulatory light chain (RLC) of sarcomeric myosin in skeletal and cardiac muscle. Phosphorylation of RLC promotes displacement of myosin cross-bridges from the thick filament backbone toward actin-containing thin filaments, increasing the probability of cross-bridge entry into force-generating states and thereby potentiating contractile force at submaximal Ca(2+) concentrations..

Function from UniProtKB (Q9H1R3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

23 statements

23 statements · 3 reference databases · Subject: MYLK2 · Sources: gene ontology, Hetionet, WikiPathways

Order

MYLK2 covaries with RAB1BProteinHetionet hetionet:covaries:81876-85366Inferred only
MYLK2 covaries with SSC5DProteinHetionet hetionet:covaries:284297-85366Inferred only
ELP1 interacts with MYLK2ProteinHetionet hetionet:interacts:8518-85366Inferred only
ESR1 interacts with MYLK2ProteinHetionet hetionet:interacts:2099-85366Inferred only
HSP90AA1 interacts with MYLK2ProteinHetionet hetionet:interacts:3320-85366Inferred only
HSP90AB1 interacts with MYLK2ProteinHetionet hetionet:interacts:3326-85366Inferred only
MAP3K3 interacts with MYLK2ProteinHetionet hetionet:interacts:4215-85366Inferred only
MEF2C interacts with MYLK2ProteinHetionet hetionet:interacts:4208-85366Inferred only
NDUFAF1 interacts with MYLK2ProteinHetionet hetionet:interacts:51103-85366Inferred only
NFKB2 interacts with MYLK2ProteinHetionet hetionet:interacts:4791-85366Inferred only
SUMO2 interacts with MYLK2ProteinHetionet hetionet:interacts:6613-85366Inferred only
MYLK2 participates in Focal adhesionPathwayWikiPathways WP306Inferred only

Show the remaining 11

MYLK2 participates in Integrin mediated cell adhesionPathwayWikiPathways WP185Inferred only
MYLK2 participates in Myometrial relaxation and contraction pathwaysPathwayWikiPathways WP289Inferred only
MYLK2 regulates positive regulation of gene expressionBiological processgene ontology Q9H1R3|GO:0010628Inferred only
MYLK2 regulates regulation of muscle filament slidingBiological processgene ontology Q9H1R3|GO:0032971Inferred only
MYLK2 increases the expression of ABCC5ProteinHetionet hetionet:regulates:85366-10057Inferred only
MYLK2 decreases the expression of CHMP4AProteinHetionet hetionet:regulates:85366-29082Inferred only
MYLK2 decreases the expression of LRP10ProteinHetionet hetionet:regulates:85366-26020Inferred only
MYLK2 increases the expression of POLE2ProteinHetionet hetionet:regulates:85366-5427Inferred only
MYLK2 increases the expression of SATB1ProteinHetionet hetionet:regulates:85366-6304Inferred only
MYLK2 increases the expression of SELLProteinHetionet hetionet:regulates:85366-6402Inferred only
MYLK2 decreases the expression of TXNDC9ProteinHetionet hetionet:regulates:85366-10190Inferred only

Reactions

3 reactions

MAM00190c+ATPMAM00191c+ADP
Catalysed by MYLK or MYLK2 or MYLK3 or MYLK4
Reaction pageLeft to rightBalance undeterminableEC 2.7.11.18cytosol
Human-GEM MAR09493CC BY 4.0Reference data
L-seryl-[myosin light chain]+ATP(4-)O-phospho-L-seryl-[myosin light chain]+ADP(3-)+hydron
Catalysed by MYLK

Other names

1 name

Resolves to: MYLK2

Also called: MLCK2

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